INT246622

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Context Info
Confidence 0.74
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 52.60 Quite High
adenocard 2 45.84 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 11 77.84 Quite High
Death 24 72.44 Quite High
Cancer 16 59.56 Quite High
Apoptosis 41 58.96 Quite High
Fatigue 1 57.08 Quite High
Obesity 10 53.24 Quite High
Stress 11 38.32 Quite Low
Lifespan 18 24.88 Low Low
Cardiovascular Disease 7 12.68 Low Low
Fatty Liver 3 11.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus resveratrol, via stimulation of the SIRT-1-mediated deacetylation of PGC-1, improves mitochondrial function and energy balance in mice (Baur et al 2006; Lagouge et al 2006) (Figure 2).
Phosphorylation (deacetylation) of SIRT-1-mediated
1) Confidence 0.74 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.11 Pain Relevance 0
Complete neuroprotection was also observed with SIRT1-H355A, another catalytically-dead mutant form of SIRT1 that is commonly used (Fig. 4) [9], [58]–[60].
Phosphorylation (form) of SIRT1
2) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.45 Pain Relevance 0.03

General Comments

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