INT246625

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.96
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Sirt1, Trp53) enzyme binding (Sirt1, Trp53) cytoplasm (Sirt1, Trp53)
nucleolus (Sirt1, Trp53) nucleus (Sirt1, Trp53) cell differentiation (Sirt1)
Sirt1 (Mus musculus)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 2 95.52 Very High Very High Very High
ischemia 3 12.40 Low Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 1 86.60 High High
Death 2 85.88 High High
Motor Neuron Diseases 1 82.24 Quite High
Disease 13 80.88 Quite High
Neurodegenerative Disease 3 79.76 Quite High
Apoptosis 9 78.64 Quite High
Alzheimer's Dementia 2 70.32 Quite High
Toxicity 1 63.20 Quite High
Aging 6 49.40 Quite Low
Neurological Disease 3 43.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most importantly, the effect of resveratrol was mediated by SIRT-1, via increased deacetylation of p53 and/or PGC-1?
SIRT-1 Positive_regulation (mediated) of Negative_regulation (deacetylation) of p53
1) Confidence 0.10 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.96 Pain Relevance 0.08

General Comments

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