INT246626

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CLCN2) transmembrane transport (CLCN2)
Anatomy Link Frequency
lumen 1
epithelial cells 1
CLCN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Onset of action 2 94.32 High High
spastic colon 22 5.00 Very Low Very Low Very Low
nud 14 5.00 Very Low Very Low Very Low
Opioid 10 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Constipation 110 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

30 5.00 Very Low Very Low Very Low
Vomiting 30 5.00 Very Low Very Low Very Low
Dyspepsia 14 5.00 Very Low Very Low Very Low
Diarrhoea 10 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 6 5.00 Very Low Very Low Very Low
Headache 4 5.00 Very Low Very Low Very Low
Abdominal Pain 4 5.00 Very Low Very Low Very Low
Flatulence 2 5.00 Very Low Very Low Very Low
Stress Incontinence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lubiprostone specifically activates ClC-2 channels on the apical membrane of epithelial cells (Cuppoletti et al 2004).
Positive_regulation (activates) of ClC-2 in epithelial cells
1) Confidence 0.48 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546479 Disease Relevance 0 Pain Relevance 0.05
Activation of ClC-2 channels causes an efflux of chloride into the lumen of the GI tract, followed by an efflux of sodium ions in order to maintain isoelectric neutrality.
Positive_regulation (Activation) of ClC-2 in lumen
2) Confidence 0.48 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546479 Disease Relevance 0 Pain Relevance 0.04

General Comments

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