INT246641

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.00
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (YWHAQ) nucleolus (YWHAQ) nucleus (YWHAQ)
protein complex (YWHAQ) cytoplasm (YWHAQ)
Anatomy Link Frequency
neurons 2
cerebrospinal fluid 1
YWHAQ (Homo sapiens)
Pain Link Frequency Relevance Heat
Pyramidal cell 12 94.84 High High
iatrogenic 5 73.92 Quite High
imagery 6 58.28 Quite High
Pain 5 20.16 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 92 99.04 Very High Very High Very High
Breast Cancer 29 96.22 Very High Very High Very High
Disease 81 95.60 Very High Very High Very High
Death 28 95.18 Very High Very High Very High
Cancer 21 91.72 High High
Dyskinesias 2 88.16 High High
Myoclonus 15 87.92 High High
Toxicity 11 87.20 High High
Dementia 21 86.72 High High
Cerebellar Diseases 3 84.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intracerebral injection of 3- and 10-fold less AAV-Tau, with consequently less expression of human protein Tau, produced a graded, lesser loss of hippocampal neurons [30].
Gene_expression (expression) of protein Tau in neurons
1) Confidence 0.58 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2938448 Disease Relevance 0.20 Pain Relevance 0.16
Occurrence of periodical spikes in EEG, observation of cortical signal alterations during diffusion weighted (DW) MRI studies, and detection of protein 14-3-3 in cerebrospinal fluid (CSF) substantiate the diagnosis.


Gene_expression (detection) of protein 14-3-3 in cerebrospinal fluid
2) Confidence 0.14 Published 2008 Journal Cases J Section Abstract Doc Link PMC2547099 Disease Relevance 0.70 Pain Relevance 0
The protein 14-3-3 could not be detected in CSF.
Neg (not) Gene_expression (detected) of protein 14-3-3
3) Confidence 0.14 Published 2008 Journal Cases J Section Body Doc Link PMC2547099 Disease Relevance 0.96 Pain Relevance 0.07
In only three patients was CSF examined for the presence of the 14-3-3 protein, a non-specific marker of neuronal cell death, which is nonetheless useful in the diagnosis of sCJD (Sanchez-Juan et al., 2006). 14-3-3 was positive and s100b was elevated in two of these 14-3-3-positive patients, while in the third, s100b and neuron-specific enolase were elevated but 14-3-3 protein was not detected.
Neg (not) Gene_expression (detected) of 14-3-3 protein in neuron associated with death
4) Confidence 0.07 Published 2008 Journal Brain Section Body Doc Link PMC2570713 Disease Relevance 0.52 Pain Relevance 0
The TACT study has a large translational project (TransTACT) investigating the concept of biologically driven chemotherapy selection, which will examine interactions between taxane benefit and the expression of tau protein,37 the AKT pathway,38 and the triple-negative phenotype.39 Other trials groups are also exploring innovative biological hypotheses in relation to individual drug sensitivity.40–42 We support the view that “one-size-fits-all” adjuvant chemotherapy trials in early breast cancer are too simple43 and we propose that future trials are designed around specific biological patient subgroups, with the aim of accelerating advances in tailored therapy.
Gene_expression (expression) of tau protein associated with breast cancer
5) Confidence 0.04 Published 2009 Journal Lancet Section Body Doc Link PMC2687939 Disease Relevance 0.62 Pain Relevance 0

General Comments

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