INT24670

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 121
Total Number 123
Disease Relevance 85.64
Pain Relevance 15.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
fibroblast 7
endometrium 4
bone marrow 4
monocytes 4
epithelial cells 4
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 488 100.00 Very High Very High Very High
bDMF 36 100.00 Very High Very High Very High
Dismenorea 15 100.00 Very High Very High Very High
tetrodotoxin 27 99.96 Very High Very High Very High
rheumatoid arthritis 435 99.84 Very High Very High Very High
Inflammation 766 99.52 Very High Very High Very High
Morphine 6 99.36 Very High Very High Very High
Angina 628 99.08 Very High Very High Very High
ischemia 141 99.04 Very High Very High Very High
chemokine 217 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1214 100.00 Very High Very High Very High
Necrosis 52 100.00 Very High Very High Very High
Dysmenorrhea 15 100.00 Very High Very High Very High
Breast Cancer 102 99.98 Very High Very High Very High
Osteoporosis 34 99.98 Very High Very High Very High
Eosinophilic Esophagitis 1060 99.92 Very High Very High Very High
Benign Prostatic Hypertrophy 579 99.84 Very High Very High Very High
Rheumatoid Arthritis 483 99.84 Very High Very High Very High
Pancreatic Cancer 285 99.84 Very High Very High Very High
Inflammatory Breast Neoplasms 279 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the control group, FGF-2 levels were detectable in only 1 of 8 joints (13%), for a concentration of 3 pg/mL.
Gene_expression (detectable) of FGF-2 in joints
1) Confidence 0.78 Published 2003 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 14676757 Disease Relevance 0 Pain Relevance 0
The expression and intensity of staining for bFGF, FGF-R, and PCNA were evaluated in the glandular epithelium and stroma of adenomyosis and endometrium.
Gene_expression (expression) of bFGF in endometrium
2) Confidence 0.75 Published 2001 Journal Menopause Section Body Doc Link 11528364 Disease Relevance 0.17 Pain Relevance 0
This study was designed to evaluate if adenomyosis expresses bFGF and FGF-R, and if present, to compare bFGF and FGF-R expression in adenomyosis and autologous endometrium.
Gene_expression (expression) of bFGF in endometrium associated with dismenorea
3) Confidence 0.75 Published 2001 Journal Menopause Section Abstract Doc Link 11528364 Disease Relevance 0.46 Pain Relevance 0.27
This study was designed to evaluate if adenomyosis expresses bFGF and FGF-R, and if present, to compare bFGF and FGF-R expression in adenomyosis and autologous endometrium.
Gene_expression (expresses) of bFGF in endometrium associated with dismenorea
4) Confidence 0.75 Published 2001 Journal Menopause Section Abstract Doc Link 11528364 Disease Relevance 0.46 Pain Relevance 0.27
OBJECTIVES: Basic fibroblast growth factor (bFGF) is an angiogenic growth factor present in human endometrium and myometrium.
Gene_expression (present) of bFGF in endometrium
5) Confidence 0.75 Published 2001 Journal Menopause Section Abstract Doc Link 11528364 Disease Relevance 0.27 Pain Relevance 0.24
FGF2 (fibroblast growth factor 2), IGF1 (insulin-like growth factor 1), and IGF2 (insulin-like growth factor 2), have altered expression levels in BPH and prostate cancer [56], [57] and men with elevated IGF-1 serum levels have an increased risk for BPH [58].
Gene_expression (expression) of fibroblast growth factor 2 in fibroblast associated with benign prostatic hypertrophy and prostate cancer
6) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 1.92 Pain Relevance 0.03
Of note, we observed a decrease in FGF-2 protein expression in response to morphine.
Gene_expression (expression) of FGF-2 associated with morphine
7) Confidence 0.75 Published 2010 Journal J. Cell. Biochem. Section Abstract Doc Link 20564181 Disease Relevance 0.86 Pain Relevance 0.77
Biotinylated HBGF2 and EGF (B-GF) were exposed to complexes of biotinylated collagen (B-COL)-avidin (A) and detected with peroxidase-labeled avidin (AP) followed by chromagen formation on nitrocellulose paper.
Gene_expression (detected) of HBGF2
8) Confidence 0.69 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2469861 Disease Relevance 0 Pain Relevance 0
Subjects were randomized 2:1 to a single dose of bFGF or placebo, injected into the left main coronary artery. bFGF doses ranged from 3 to 100 microg/kg, increasing in half-log increments. bFGF was generally well tolerated at doses of 3 to 30 microg/kg.
Gene_expression (ranged) of bFGF in coronary artery
9) Confidence 0.67 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10856385 Disease Relevance 0.72 Pain Relevance 0.25
Bonferroni post hoc comparison in bFGF expression between the groups CAD SA – CAD UA and noCAD – CAD SA revealed a statistically significant difference (p = 0.003) and (p = 0.016) respectively.
Gene_expression (expression) of bFGF associated with coronary artery disease
10) Confidence 0.67 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.33 Pain Relevance 0
The expression of VEGF, bFGF and TGF-?
Gene_expression (expression) of bFGF
11) Confidence 0.67 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.05 Pain Relevance 0.18
A representative semi-quantitative RT-PCR assay demonstrating a range of differences in the production of VEGF, bFGF and TGF-?
Gene_expression (production) of bFGF
12) Confidence 0.67 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.53 Pain Relevance 0.27
The effect of glucose and statins in the expression of VEGF and bFGF
Gene_expression (expression) of bFGF
13) Confidence 0.67 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.06 Pain Relevance 0.16
The fact that no significant differences among these secondary outcome measures for the 4 groups showed that FGF-2 administration did not cause abnormal healing of periodontium following periodontal surgery.
Gene_expression (administration) of FGF-2 in periodontium
14) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432040 Disease Relevance 0.31 Pain Relevance 0
The expression of FGF2 in BPH has been previously reported by several groups [74], [75], [76].
Gene_expression (expression) of FGF2 associated with benign prostatic hypertrophy
15) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.80 Pain Relevance 0
Such a general distribution broadly agrees with our observations, which show the expression of FGF2 in both velvet and mesenchyme.
Gene_expression (expression) of FGF2 in mesenchyme
16) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0.20 Pain Relevance 0.07
OBJECTIVE: We sought to elucidate the levels of fibroblast growth factor 2 (FGF-2) in synovial fluid taken from internally deranged human temporomandibular joints (TMJs) and to discuss the role of FGF-2 in the pathogenesis of internal derangement.
Gene_expression (levels) of FGF-2 in synovial fluid
17) Confidence 0.60 Published 2003 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 14676757 Disease Relevance 0.07 Pain Relevance 0.07
OBJECTIVE: We sought to elucidate the levels of fibroblast growth factor 2 (FGF-2) in synovial fluid taken from internally deranged human temporomandibular joints (TMJs) and to discuss the role of FGF-2 in the pathogenesis of internal derangement.
Gene_expression (levels) of fibroblast growth factor 2 in synovial fluid
18) Confidence 0.60 Published 2003 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 14676757 Disease Relevance 0.07 Pain Relevance 0.07
Levels of fibroblast growth factor 2 in synovial fluids in human patients with internal derangement of the temporomandibular joint.
Gene_expression (Levels) of fibroblast growth factor 2 in synovial fluids associated with snapping jaw
19) Confidence 0.60 Published 2003 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Title Doc Link 14676757 Disease Relevance 0.10 Pain Relevance 0.10
Among the four epidermal growth factors, 18 angiogenic genes and six cytokines, only seven genes (namely IL-8, VEGF, bFGF, angiopoietin 1, flt-1, Tie-2 and Tie-1) are overexpressed in WIBC-9 when compared with non-inflammatory models [37].
Gene_expression (overexpressed) of bFGF associated with inflammation and cytokine
20) Confidence 0.59 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.27 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox