INT24671

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Context Info
Confidence 0.35
First Reported 1989
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 8.73
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF2) extracellular space (FGF2) extracellular region (FGF2)
nucleus (FGF2) cytoplasm (FGF2)
Anatomy Link Frequency
glial cell 1
brain 1
extracellular matrix 1
fibroblast 1
skin 1
FGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 33 100.00 Very High Very High Very High
Nerve growth factor 9 100.00 Very High Very High Very High
fibrosis 8 100.00 Very High Very High Very High
Hyperalgesia 1 100.00 Very High Very High Very High
cINOD 3 97.60 Very High Very High Very High
Migraine 4 96.72 Very High Very High Very High
Pain 13 88.72 High High
ischemia 8 87.56 High High
Analgesic 1 25.00 Low Low
Chronic pancreatitis 33 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 12 100.00 Very High Very High Very High
Hyperalgesia 1 100.00 Very High Very High Very High
Pancreatic Cancer 168 99.00 Very High Very High Very High
Diabetes Mellitus 32 98.72 Very High Very High Very High
Eosinophilic Esophagitis 212 98.12 Very High Very High Very High
Epilepsy 1 96.92 Very High Very High Very High
Headache 4 96.72 Very High Very High Very High
Cancer 78 96.24 Very High Very High Very High
Ganglion Cysts 2 95.44 Very High Very High Very High
Gastroesophageal Reflux Disease 72 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Before BMI, the plasma VEGF and bFGF concentrations were much greater in the ischemic leg than in the other lower limb, but decreased to the same concentrations as those in the contralateral lower extremity after BMI.
bFGF Binding (decreased) of in extremity
1) Confidence 0.35 Published 2006 Journal Angiology Section Abstract Doc Link 16518534 Disease Relevance 0.33 Pain Relevance 0.21
FGFBP1 and FGFR1 interact with fibroblast growth factors FGF1 and FGF2, and it has been suggested that the fibroblast growth factors could serve as the angiogenic switch in human cancer [41–43].
FGF2 Binding (interact) of in fibroblast associated with cancer
2) Confidence 0.33 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2634794 Disease Relevance 0.94 Pain Relevance 0
Diabetes was the only covariate found to influence greatly the variance improving considerably the significance of our model both for VEGF (p = 0.001) (Figure 3B) and bFGF (p = 0.000) (Figure 3D).
bFGF Binding (improving) of associated with diabetes mellitus
3) Confidence 0.32 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.57 Pain Relevance 0
Biotinylation of collagen and the growth factors allows immobilization of HBGF2 and EGF by high affinity binding of tetravalent avidin.
HBGF2 Binding (binding) of
4) Confidence 0.32 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2469861 Disease Relevance 0 Pain Relevance 0
Binding of biotinylated HBGF2 and EGF was specific (*, P less than 0.05), proportional to the concentration of biotinylated collagen, and resistant to ionic (NaCl) displacement.
HBGF2 Binding (Binding) of
5) Confidence 0.32 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2469861 Disease Relevance 0 Pain Relevance 0.06
Specific binding of biotinylated HBGF2, EGF, or other biologically active molecules (antibiotics, NSAIDs) to implantable collagen may provide a mechanism for positive therapeutic modulation of wound healing, including repair of full-thickness skin wounds with cultured cell-collagen composite grafts.
HBGF2 Binding (binding) of in skin associated with injury, wound healing and cinod
6) Confidence 0.32 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2469861 Disease Relevance 0.19 Pain Relevance 0.10
The immunostaining for TIMP2, FGF2, and SMOC1 was often quite marked.
FGF2 Binding (immunostaining) of
7) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.78 Pain Relevance 0
Past research has demonstrated that bFGF is a pro-fibrotic cytokine that may promote both fibrosis and angiogenesis by binding to the extracellular matrix [25,26].
bFGF Binding (binding) of in extracellular matrix associated with fibrosis and cytokine
8) Confidence 0.26 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.42 Pain Relevance 0.21
In addition SNP caused an elevation of glial cell response mRNAs primarily associated with Müller cells (GFAP, CNTF, bFGF) as well as caspase-3 and Bcl-2.
bFGF Binding (associated) of in glial cell
9) Confidence 0.21 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17562394 Disease Relevance 0.53 Pain Relevance 0
Since the FGF-9 antibody was made against the entire length of the amino acid, it is likely that homologous isoforms of FGF such as bFGF were also recognized.
bFGF Spec (likely) Binding (recognized) of
10) Confidence 0.20 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.15 Pain Relevance 0.11
It is conceivable that the HSPG/FGF receptor complex can facilitate FGF-2 signaling, but may not be strictly required for binding of FGF-2 to its receptor; it only increases the affinity of the FGF-2/FGF receptor interaction to a certain degree.
FGF-2 Binding (interaction) of
11) Confidence 0.17 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.40 Pain Relevance 0
It is conceivable that the HSPG/FGF receptor complex can facilitate FGF-2 signaling, but may not be strictly required for binding of FGF-2 to its receptor; it only increases the affinity of the FGF-2/FGF receptor interaction to a certain degree.
FGF-2 Binding (binding) of
12) Confidence 0.17 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.35 Pain Relevance 0
Furthermore, the correlation analysis has been performed for the total protein content and the concentrations of aggrecan, bFGF, IGF-I, and IL-1?
bFGF Binding (aggrecan) of
13) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.06 Pain Relevance 0.13
Furthermore, the correlation analysis has been performed for the total protein content and the concentrations of aggrecan, bFGF, IGF-I, and IL-1?
bFGF Binding (concentrations) of
14) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2920860 Disease Relevance 0.06 Pain Relevance 0.13
Hsulf-1 decreases FGF-2 mediated cell proliferation and signaling in Panc-1 pancreatic cancer cells
FGF-2 Binding (proliferation) of associated with pancreatic cancer
15) Confidence 0.13 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.41 Pain Relevance 0
Attention is drawn to a possible role for neurotrophins, such as the hyperalgesia-provoking nerve growth factor (NGF) in particular, as well as basic fibroblast growth factor (bFGF) and brain-derived neurotrophic factor (BDNF).
bFGF Spec (possible) Binding (role) of in brain associated with hyperalgesia and nerve growth factor
16) Confidence 0.07 Published 1995 Journal Cephalalgia Section Abstract Doc Link 7585920 Disease Relevance 0.54 Pain Relevance 0.49

General Comments

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