INT246723

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Context Info
Confidence 0.63
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 7.27
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton (Arc)
cytoskeleton organization (Arc) cytoplasm (Arc)
Anatomy Link Frequency
dendrites 2
neurons 2
neuronal 1
periventricular nucleus 1
hypothalamus 1
Arc (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 23 99.76 Very High Very High Very High
Dorsal horn neuron 18 99.00 Very High Very High Very High
Enkephalin 27 96.88 Very High Very High Very High
Spinal cord 75 96.20 Very High Very High Very High
gABA 13 95.68 Very High Very High Very High
Glutamate 24 94.40 High High
allodynia 6 88.68 High High
Thermal hyperalgesia 3 88.12 High High
Neuropathic pain 12 86.08 High High
Dorsal horn 36 81.00 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 982 100.00 Very High Very High Very High
Nervous System Injury 18 93.36 High High
Targeted Disruption 119 91.16 High High
Neuropathic Pain 21 88.68 High High
Hyperalgesia 9 88.12 High High
Generalized Anxiety Disorder 3 87.12 High High
Nociception 123 74.64 Quite High
INFLAMMATION 18 70.96 Quite High
Feminization 8 69.64 Quite High
Non-genital Cutaneous Warts 3 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since we found a low level of colocalization of Arc/Arg3.1 with GABAergic neurons, it is not unlikely that several of the enkephalinergic neurons in the spinal cord that express Arc/Arg3.1 also use glutamate as a transmitter.
Localization (colocalization) of Arc/Arg3.1 in neurons associated with glutamate, aids-related complex, gabaergic and spinal cord
1) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.80 Pain Relevance 1.28
We did not observe any labeling indicative of localization of Arc/Arg3.1 in intermediate or distal dendrites.
Localization (localization) of Arc/Arg3.1 in dendrites associated with aids-related complex
2) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 0.93 Pain Relevance 0.08
Here, we localize endogenous PER2 expression to the ME/PT and ependymal cell layer and, importantly, discriminate single cells in the ArcD, ArcL and DMHc.
Localization (localize) of ArcL in ependymal cell associated with aids-related complex
3) Confidence 0.59 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.33 Pain Relevance 0
All micro-dissected DMH (n = 13) and Arc complex (n = 10) cultures were rhythmic (Fig. 5C and 5D, Table 1).
Localization (dissected) of Arc associated with aids-related complex
4) Confidence 0.59 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.64 Pain Relevance 0
Further, single cells were readily discriminated in both the DMH and Arc (Fig. 2A and 2C).
Localization (discriminated) of Arc associated with aids-related complex
5) Confidence 0.59 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.50 Pain Relevance 0
In this experiment, the colocalization of Arc/Arg3.1 with various neuronal markers was investigated (Fig. 5A-E).
Spec (investigated) Localization (colocalization) of Arc/Arg3.1 in neuronal associated with aids-related complex
6) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.59 Pain Relevance 0.45
Arc mRNA is transported throughout neurons, and Arc protein can be synthesized in dendrites (Dynes & Steward 2007).
Localization (transported) of Arc mRNA in dendrites associated with aids-related complex
7) Confidence 0.46 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.73 Pain Relevance 0.07
Coronal sections (20 ┬Ám) of the AVPV and ARC were cut on a cryostat, thaw-mounted onto SuperFrost Plus slides (VWR Scientific, West Chester, PA), and stored at ?
Localization (sections) of ARC associated with aids-related complex
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.26 Pain Relevance 0
The second population of neurons immunoreactive for kisspeptin, in the ARC, localized more caudally and separate from the AVPV [7], was stained by ICC in female and male WT and hpg mice.
Localization (localized) of ARC in neurons associated with aids-related complex
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.41 Pain Relevance 0
Finally, we observed that the kisspeptin immunoreactive staining pattern in the ARC is dependent upon gonadal status and is reversible, as kisspeptin staining in the ARC of hpg mice treated with E2 is converted to a WT pattern.
Localization (treated) of ARC in gonadal associated with aids-related complex
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.35 Pain Relevance 0.04
Distinct from the kisspeptin neurons in the ARC, a discrete, second kisspeptin population is localized in the anteroventral periventricular nucleus (AVPV).
Localization (localized) of ARC in periventricular nucleus associated with aids-related complex
11) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.53 Pain Relevance 0
m in the ARC of the hypothalamus were processed for the colocalization of c-Fos, NPY, and POMC.
Localization (colocalization) of ARC in hypothalamus associated with aids-related complex
12) Confidence 0.29 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.19 Pain Relevance 0

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