INT246749

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.40
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tsc2) signal transduction (Tsc2) Golgi apparatus (Tsc2)
nucleus (Tsc2) intracellular (Tsc2) protein complex (Tsc2)
Anatomy Link Frequency
muscle 2
renal cortex 2
Tsc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 1 85.36 High High
Paracetamol 60 73.16 Quite High
anesthesia 9 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tuberous Sclerosis 12 100.00 Very High Very High Very High
Hyperglycemia 58 99.60 Very High Very High Very High
Diabetes Mellitus 351 99.14 Very High Very High Very High
Injury 36 86.68 High High
Body Weight 22 83.44 Quite High
Apoptosis 31 81.92 Quite High
Aging 38 77.24 Quite High
Stress 65 74.36 Quite High
Frailty 5 71.36 Quite High
Death 15 54.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This possibility is given by the fact that Wnt stimulates the mTOR signalling pathway via inhibiting GSK3 phosphorylation of TSC2.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of TSC2
1) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0 Pain Relevance 0.04
Interestingly, these data do not appear to predict down-stream Akt signaling since the phosphorylation level of mTOR (Ser2448) [9] (Figure 2A), tuberous sclerosis complex-2 (TSC2) and forkhead box O1 (FoxO1) (data not shown) was lower in the very aged muscle.
Negative_regulation (level) of Phosphorylation (phosphorylation) of TSC2 in muscle associated with tuberous sclerosis
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.43 Pain Relevance 0.07
Moreover, pretreatment of the cells with NAC inhibited Akt and tuberin phosphorylation and upregulation of OGG1 protein expression in cells exposed to high glucose (Fig. 7D).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of tuberin
3) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
The observation that PI 3-kinase and Akt inhibitors block the effect of high glucose on tuberin phosphorylation indicates that the PI 3-kinase/Akt pathway mediates the action of high glucose on tuberin.
Negative_regulation (block) of Phosphorylation (phosphorylation) of tuberin
4) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.47 Pain Relevance 0
Therefore, tuberin deficiency, through its phosphorylation, is upstream of OGG1 in the pathway linking high glucose to DNA damage.
Negative_regulation (deficiency) of Phosphorylation (phosphorylation) of tuberin
5) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.28 Pain Relevance 0
Diabetes is associated with an increase in Akt and tuberin phosphorylation and OGG1 downregulation in the renal cortex.
Negative_regulation (downregulation) of Phosphorylation (phosphorylation) of tuberin in renal cortex associated with diabetes mellitus
6) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.43 Pain Relevance 0
Phosphorylation of tuberin and downregulation of OGG1 are redox sensitive in MCT cells.
Negative_regulation (downregulation) of Phosphorylation (Phosphorylation) of tuberin
7) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
The antioxidant N-acetylcysteine significantly inhibited ROS generation, Akt/protein kinase B, and tuberin phosphorylation and resulted in deceased 8-oxodG accumulation and upregulation of OGG1 protein expression.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of tuberin
8) Confidence 0.18 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551671 Disease Relevance 0.44 Pain Relevance 0
Moreover, the effect of high glucose on ROS generation, Akt/tuberin phosphorylation, OGG1 downregulation, and 8-oxodG accumulation is markedly reduced by the antioxidant NAC.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of tuberin
9) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.43 Pain Relevance 0
To test the hypothesis that hyperglycemia stimulates Akt and tuberin phosphorylation and downregulation of OGG1 in vivo, we used a rat model of type 1 diabetes.
Negative_regulation (downregulation) of Phosphorylation (phosphorylation) of tuberin associated with hyperglycemia and diabetes mellitus
10) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.54 Pain Relevance 0
Of interest is that insulin- or IGF-IĀ–induced tuberin phosphorylation is also inhibited by the PI 3-kinase inhibitor LY294002 (45).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of tuberin
11) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.37 Pain Relevance 0

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