INT246761

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tsc2) signal transduction (Tsc2) Golgi apparatus (Tsc2)
nucleus (Tsc2) intracellular (Tsc2) protein complex (Tsc2)
Anatomy Link Frequency
renal cortex 2
Tsc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 3 99.58 Very High Very High Very High
Diabetes Mellitus 39 98.76 Very High Very High Very High
Angiomyolipoma 12 93.84 High High
Cancer 21 91.68 High High
Disease 21 86.92 High High
Cyst 4 70.44 Quite High
Tuberous Sclerosis 11 50.00 Quite Low
Hyperglycemia 6 34.80 Quite Low
Myeloid Leukemia 5 31.76 Quite Low
Syndrome 2 14.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
genotype and the severity of renal disease in TSC patients who had TSC2 mutations; they found an association between IFN-?
Positive_regulation (had) of Gene_expression (mutations) of TSC2 associated with renal disease
1) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.82 Pain Relevance 0
RESULTS—In the renal cortex of diabetic rats, the increase in Akt phosphorylation is associated with enhanced phosphorylation of tuberin, decreased OGG1 protein expression, and 8-oxodG accumulation.
Positive_regulation (enhanced) of Gene_expression (expression) of tuberin in renal cortex associated with diabetes mellitus
2) Confidence 0.21 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551671 Disease Relevance 0.35 Pain Relevance 0

General Comments

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