INT246763

Context Info Confidence 0.53 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 4 Disease Relevance 1.22 Pain Relevance 0

nucleoplasm (Akt2) transport (Akt2) mitochondrion (Akt2) carbohydrate metabolic process (Akt2) cytoplasm (Akt2) cytosol (Akt2)

Anatomy Link Frequency endothelial cells 1 Akt2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 28 32.96 ischemia 27 5.00 anesthesia 13 5.00 isoflurane 6 5.00 ketamine 3 5.00 Potency 3 5.00 antagonist 3 5.00 Catecholamine 3 5.00

Disease Link Frequency Relevance Heat Myocardial Infarction 312 80.80 Diabetes Mellitus 66 66.72 Insulin Resistance 36 58.16 Injury 10 53.04 Stress 7 52.20 Body Weight 41 50.76 Cardiovascular Disease 12 50.08 Hyperglycemia 18 44.48 Apoptosis 14 26.24 Weight Loss 15 22.40

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

However, studies in normal primary human coronary artery endothelial cells in vitro have demonstrated a similar lack of overt exenatide effect on eNOS and AKT2 protein expression on a background of enhanced activation of both proteins [39].

Gene_expression (expression) of AKT2 protein in endothelial cells

1) Confidence 0.53 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.30 Pain Relevance 0

No differences in the protein expression of AKT2, SERCA2a, or PI3Kbeta were observed, and the observed trend towards reduction in eNOS expression might be expected to diminish cardiac function rather than improve it.

Gene_expression (expression) of AKT2

2) Confidence 0.53 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.30 Pain Relevance 0

Immunoblot analysis of cardiac tissue did not demonstrate any significant changes in expression of GLUT4, AKT2, SERCA2a or PI3Kbeta with GLP-1 or AC3174 treatment (Figure 4), although trends towards decreased GLUT1 and eNOS expression were noted.

Gene_expression (expression) of AKT2

3) Confidence 0.41 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.29 Pain Relevance 0

The concept that the PI 3-kinase/Akt pathway regulates tuberin is supported by other observations that the expression of a constitutively active PI 3-kinase or active Akt, including Akt1 or Akt2, induce tuberin phosphorylation (27).

Gene_expression (expression) of Akt2

4) Confidence 0.30 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.32 Pain Relevance 0

General Comments

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