INT246763

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt2) transport (Akt2) mitochondrion (Akt2)
carbohydrate metabolic process (Akt2) cytoplasm (Akt2) cytosol (Akt2)
Anatomy Link Frequency
endothelial cells 1
Akt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 28 32.96 Quite Low
ischemia 27 5.00 Very Low Very Low Very Low
anesthesia 13 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 312 80.80 Quite High
Diabetes Mellitus 66 66.72 Quite High
Insulin Resistance 36 58.16 Quite High
Injury 10 53.04 Quite High
Stress 7 52.20 Quite High
Body Weight 41 50.76 Quite High
Cardiovascular Disease 12 50.08 Quite High
Hyperglycemia 18 44.48 Quite Low
Apoptosis 14 26.24 Quite Low
Weight Loss 15 22.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, studies in normal primary human coronary artery endothelial cells in vitro have demonstrated a similar lack of overt exenatide effect on eNOS and AKT2 protein expression on a background of enhanced activation of both proteins [39].
Gene_expression (expression) of AKT2 protein in endothelial cells
1) Confidence 0.53 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.30 Pain Relevance 0
No differences in the protein expression of AKT2, SERCA2a, or PI3Kbeta were observed, and the observed trend towards reduction in eNOS expression might be expected to diminish cardiac function rather than improve it.
Gene_expression (expression) of AKT2
2) Confidence 0.53 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.30 Pain Relevance 0
Immunoblot analysis of cardiac tissue did not demonstrate any significant changes in expression of GLUT4, AKT2, SERCA2a or PI3Kbeta with GLP-1 or AC3174 treatment (Figure 4), although trends towards decreased GLUT1 and eNOS expression were noted.


Gene_expression (expression) of AKT2
3) Confidence 0.41 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.29 Pain Relevance 0
The concept that the PI 3-kinase/Akt pathway regulates tuberin is supported by other observations that the expression of a constitutively active PI 3-kinase or active Akt, including Akt1 or Akt2, induce tuberin phosphorylation (27).
Gene_expression (expression) of Akt2
4) Confidence 0.30 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.32 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox