INT24677

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.73
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
nerve 2
trigeminal nerves 2
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 40 100.00 Very High Very High Very High
qutenza 30 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Serotonin 3 99.32 Very High Very High Very High
tetrodotoxin 4 98.92 Very High Very High Very High
substance P 14 97.76 Very High Very High Very High
narcan 1 97.44 Very High Very High Very High
vagus nerve 1 91.44 High High
headache 6 77.88 Quite High
Neuropeptide 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Diffuse Scleroderma 1 99.84 Very High Very High Very High
Heart Rate Under Development 5 98.40 Very High Very High Very High
Systemic Sclerosis 3 96.40 Very High Very High Very High
Ganglion Cysts 1 93.84 High High
Primary Headache Disorders 1 90.04 High High
Headache 2 50.00 Quite Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low
Vomiting 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[The thermoregulatory effectiveness of calcitonin in progressive scleroderma].
Regulation (thermoregulatory) of Negative_regulation (effectiveness) of calcitonin associated with diffuse scleroderma
1) Confidence 0.44 Published 1989 Journal Z. Hautkr. Section Title Doc Link 2669402 Disease Relevance 0.38 Pain Relevance 0.08
Blockade of CGRP receptors (CGRP 8-37, 100 microg/kg i.v.) did not alter gastric emptying in control animals but significantly prevented endotoxin-induced inhibition of gastric emptying.
Neg (not) Regulation (alter) of Negative_regulation (Blockade) of CGRP
2) Confidence 0.44 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11284441 Disease Relevance 0.09 Pain Relevance 0.47
Capsaicin inhibition exhibited a marked desensitization while the effect of CGRP was still evident after capsaicin-desensitization. 5 The inhibitory effect of capsaicin or CGRP on the Kassinin-stimulated rhythmic contractions of the rat isolated vas deferens was unaffected by a previous exposure to tetrodotoxin (0.5 microM). 6 Storage at 4 degrees C for 24 h produced a 65% reduction of the response of the rat isolated vas deferens to nerve-stimulation.
Regulation (unaffected) of Negative_regulation (effect) of CGRP in nerve associated with tetrodotoxin, qutenza and calcitonin gene-related peptide
3) Confidence 0.40 Published 1987 Journal J Auton Pharmacol Section Abstract Doc Link 3429461 Disease Relevance 0 Pain Relevance 1.62
The inhibitory effect of CGRP was not affected by cervical vagotomy, hexamethonium, atropine, propranolol, or naloxone.
Neg (not) Regulation (affected) of Negative_regulation (effect) of CGRP associated with narcan and calcitonin gene-related peptide
4) Confidence 0.24 Published 1989 Journal Regul. Pept. Section Abstract Doc Link 2470120 Disease Relevance 0 Pain Relevance 0.72
The influence of a specific antagonist of CGRP receptors, CGRP8-37 (10(-8) M), on the pulmonary edema induced by these mediators was also considered.
Regulation (influence) of Negative_regulation (antagonist) of CGRP associated with heart rate under development, antagonist and calcitonin gene-related peptide
5) Confidence 0.23 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7518513 Disease Relevance 0.17 Pain Relevance 1.00
It is likely that direct blockade of CGRP release by inhibition of trigeminal nerves would be similarly effective in both migraine and cluster headache.
Regulation (effective) of Negative_regulation (blockade) of CGRP in trigeminal nerves
6) Confidence 0.04 Published 2005 Journal Curr. Opin. Neurol. Section Body Doc Link 15891413 Disease Relevance 0.09 Pain Relevance 0

General Comments

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