INT246774

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tsc2) signal transduction (Tsc2) Golgi apparatus (Tsc2)
nucleus (Tsc2) intracellular (Tsc2) protein complex (Tsc2)
Anatomy Link Frequency
renal cortex 1
epithelial cells 1
Tsc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
transdermal 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 42 99.68 Very High Very High Very High
Diabetes Mellitus 195 99.54 Very High Very High Very High
Hyperglycemia 30 99.16 Very High Very High Very High
Anaplastic Astrocytoma 12 98.54 Very High Very High Very High
Cyst 8 94.20 High High
Stress 39 88.00 High High
Cancer 45 87.88 High High
Renal Disease 12 83.28 Quite High
Hamartoma 16 80.48 Quite High
Injury 20 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Large rearrangements of TSC2 were defined in 3 of these patients.
Positive_regulation (rearrangements) of TSC2
1) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.56 Pain Relevance 0
On the other hand, recent evidence suggests that both tuber giant cells and SEGA cells have similar immunophenotypes, and SEGAs commonly sustain two-hit inactivation of either TSC1 or TSC2.
Positive_regulation (inactivation) of TSC2 associated with anaplastic astrocytoma
2) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.40 Pain Relevance 0
In summary, our data provide the first evidence that hyperglycemia and high glucose lead to phosphorylation/inactivation of tuberin and downregulation of DNA repair enzyme OGG1 via the redox-dependent activation of Akt (Fig. 9).
Positive_regulation (inactivation) of tuberin associated with hyperglycemia
3) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.56 Pain Relevance 0
Phosphorylation of tuberin by Akt affects its function through at least two mechanisms: first, phosphorylation decreases the activity of tuberin; second, phosphorylation destabilizes tuberin by disrupting the complex formation between hamartin and tuberin, resulting in ubiquitination of free tuberin and its degradation by the proteosome (27).
Positive_regulation (destabilizes) of tuberin
4) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.13 Pain Relevance 0
CONCLUSIONS—Hyperglycemia in type 1 diabetes and treatment of proximal tubular epithelial cells with high glucose leads to phosphorylation/inactivation of tuberin and downregulation of OGG1 via a redox-dependent activation of Akt in renal tubular epithelial cells.
Positive_regulation (inactivation) of tuberin in epithelial cells associated with hyperglycemia and diabetes mellitus
5) Confidence 0.21 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551671 Disease Relevance 0.38 Pain Relevance 0
Moreover, the increase in phosphorylated Akt and phosphorylated tuberin is associated with a decrease in OGG1 expression in the cells incubated with 25 mmol/l glucose for 60 min (Fig. 8A).
Positive_regulation (increase) of tuberin
6) Confidence 0.20 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
Diabetes is associated with an increase in Akt and tuberin phosphorylation and OGG1 downregulation in the renal cortex.
Positive_regulation (increase) of tuberin in renal cortex associated with diabetes mellitus
7) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.37 Pain Relevance 0

General Comments

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