INT246787

Context Info Confidence 0.10 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.16 Pain Relevance 0

cytoplasm (Akt2, Tsc2) cytosol (Akt2, Tsc2) nucleus (Akt2, Tsc2) nucleoplasm (Akt2) transport (Akt2) mitochondrion (Akt2)

Akt2 (Rattus norvegicus) Tsc2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 39 56.08 Injury 4 49.72 Stress 7 48.88 Apoptosis 2 28.80 Hyperglycemia 6 5.00 Body Weight 2 5.00 Renal Disease 2 5.00 Targeted Disruption 1 5.00 Death 1 5.00 Adhesions 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The concept that the PI 3-kinase/Akt pathway regulates tuberin is supported by other observations that the expression of a constitutively active PI 3-kinase or active Akt, including Akt1 or Akt2, induce tuberin phosphorylation (27).

Akt2 Positive_regulation (induce) of Phosphorylation (phosphorylation) of tuberin

1) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.16 Pain Relevance 0

General Comments

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