INT246794

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) Golgi apparatus (Tsc2) intracellular (Tsc2)
protein complex (Tsc2) cytoplasm (Tsc2) cell proliferation (Ros1)
Ros1 (Rattus norvegicus)
Tsc2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 21 96.88 Very High Very High Very High
Hyperglycemia 18 93.52 High High
Diabetes Mellitus 117 89.08 High High
Death 3 77.04 Quite High
Apoptosis 6 76.60 Quite High
Injury 12 75.36 Quite High
Body Weight 6 5.00 Very Low Very Low Very Low
Renal Disease 6 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Adhesions 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Importantly, we show that ROS, and specifically hydrogen peroxide, directly induce Akt activation and tuberin phosphorylation, resulting in downregulation of OGG1 in MCT cells, indicating that ROS are potential upstream mediators of the effects of high glucose on oxidative DNA damage.
ROS Positive_regulation (induce) of Phosphorylation (phosphorylation) of tuberin
1) Confidence 0.03 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.66 Pain Relevance 0
We next investigated a potential role for ROS in Akt and tuberin phosphorylation and downregulation of OGG1.
ROS Spec (investigated) Positive_regulation (role) of Phosphorylation (phosphorylation) of tuberin
2) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
ROS are required for high glucoseĀ–induced Akt and tuberin phosphorylation and OGG1 downregulation in MCT cells.
ROS Positive_regulation (required) of Phosphorylation (phosphorylation) of tuberin
3) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0

General Comments

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