INT246846

Context Info Confidence 0.39 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.08

cytosol (PIK3CA, Irs1) signal transduction (PIK3CA, Irs1) plasma membrane (Irs1) nucleus (Irs1) cytoplasm (Irs1) signal transducer activity (Irs1)

PIK3CA (Homo sapiens) Irs1 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2 82.00 tolerance 7 5.00 ketamine 2 5.00 anesthesia 1 5.00 Kinase C 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Hyperinsulinism 2 85.32 Diabetes Mellitus 7 58.08 Insulin Resistance 24 50.00 Targeted Disruption 8 50.00 Obesity 8 49.36 Impaired Glucose Tolerance 9 5.00 Body Weight 4 5.00 Rheumatoid Arthritis 3 5.00 Necrosis 1 5.00 Cancer 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ala mice also showed an increased association between IRS-1 and the p85 subunit of PI3-kinase, which reflects increased interaction between IRS-1 and PI 3-kinase likely due to the Ser612?

PI 3-kinase Binding (interaction) of IRS-1

1) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.14 Pain Relevance 0.08

General Comments

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