INT24685

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 7.76
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
plasma 2
hepatocytes 1
platelets 1
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 49 100.00 Very High Very High Very High
metalloproteinase 12 100.00 Very High Very High Very High
Inflammation 82 99.16 Very High Very High Very High
cytokine 33 98.80 Very High Very High Very High
Angina 7 82.36 Quite High
rheumatoid arthritis 1 78.04 Quite High
Arthritis 1 67.52 Quite High
abdominal pain 1 66.64 Quite High
Inflammatory response 8 63.44 Quite High
Spinal cord 7 52.80 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 59 100.00 Very High Very High Very High
Abdominal Injuries 23 100.00 Very High Very High Very High
Myocardial Infarction 20 100.00 Very High Very High Very High
INFLAMMATION 94 99.48 Very High Very High Very High
Injury 83 99.04 Very High Very High Very High
Renal Disease 12 97.76 Very High Very High Very High
Thrombosis 2 97.48 Very High Very High Very High
Gunshot Wounds 21 95.56 Very High Very High Very High
Atherosclerosis 4 95.40 Very High Very High Very High
Increased Venous Pressure Under Development 1 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Localization (tissue) of PAI1 associated with metalloproteinase
1) Confidence 0.59 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
Genes such as gelatinase A (MMP2), cathepsin L, tissue inhibitor metalloproteinases 2 (TIMP2) and 3 (TIMP3), plasminogen activator inhibitor1 (PAI1), tissue type plasminogen activator (tPA), urokinase plasminogen activator (uPA), endothelin 1, calponin, carboxypeptidase D and calponin acidic were down regulated.
Localization (tissue) of plasminogen activator inhibitor1 associated with metalloproteinase
2) Confidence 0.59 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548144 Disease Relevance 0 Pain Relevance 0.05
The results suggest that insulin stimulates synthesis and release of free PAI-1 (probably via hepatocytes as previously shown with cell culture) and that endothelial cell synthesis and release of t-PA, together with PAI-1, reflects a nonspecific acute-phase response to chronic vascular disease.
Localization (release) of PAI in hepatocytes associated with increased venous pressure under development
3) Confidence 0.57 Published 1989 Journal Arteriosclerosis Section Abstract Doc Link 2470343 Disease Relevance 0.54 Pain Relevance 0.24
An impaired fibrinolytic function, as evidenced by increased plasma concentrations of PAI-1, tPA antigen and tPA/PAI-1 complex, or a decreased capacity to release active tPA on exercise, is more common in individuals suffering from myocardial infarction.
Localization (release) of PAI-1 in plasma associated with myocardial infarction
4) Confidence 0.51 Published 1999 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 10389198 Disease Relevance 0.50 Pain Relevance 0.08
An impaired fibrinolytic function, as evidenced by increased plasma concentrations of PAI-1, tPA antigen and tPA/PAI-1 complex, or a decreased capacity to release active tPA on exercise, is more common in individuals suffering from myocardial infarction.
Localization (release) of PAI-1 in plasma associated with myocardial infarction
5) Confidence 0.51 Published 1999 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 10389198 Disease Relevance 0.50 Pain Relevance 0.08
More specifically related to the urinary tract and fibrosis, both Serpine1 and TGF-?
Localization (related) of Serpine1 associated with fibrosis
6) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.72 Pain Relevance 0.18
These results suggest that the PAI-1 that has accumulated in platelets at the onset of AMI might be released in large amounts into the plasma, resulting in an increase in thrombus formation.
Localization (released) of PAI-1 in platelets associated with thrombosis and myocardial infarction
7) Confidence 0.32 Published 2000 Journal Jpn. Circ. J. Section Abstract Doc Link 10952148 Disease Relevance 1.06 Pain Relevance 0
Because t-PA antigen levels and PAI-1 activity were highest in the morning, the variation in t-PA activity was probably not due to decreased secretion of t-PA but instead to changes in the secretion of PAI-1.
Localization (secretion) of PAI-1
8) Confidence 0.22 Published 1989 Journal Circulation Section Abstract Doc Link 2491971 Disease Relevance 0.15 Pain Relevance 0.07
PAI-1 is paracrine secretion of pro- and antiinflammatory cytokines, thereby playing a possible role in the adiposity-related inflammation and atherosclerosis.
Localization (secretion) of PAI-1 associated with inflammation, atherosclerosis and cytokine
9) Confidence 0.20 Published 2009 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 19033264 Disease Relevance 3.01 Pain Relevance 0.53
Western blotting confirmed the effects of MPA and thrombin in elevating secreted levels of PAI-1.
Localization (secreted) of PAI-1
10) Confidence 0.20 Published 2007 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 17403427 Disease Relevance 0 Pain Relevance 0
FAST can be a useful initial diagnostic study after PAI but due to its low sensitivity it cannot be relied upon for distinguishing PAI patients who may or may not need surgical exploration.
Localization (relied) of PAI associated with abdominal injuries and injury
11) Confidence 0.18 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2674409 Disease Relevance 1.27 Pain Relevance 0.03
 ; PAI-1 (sense) 5?
Localization (sense) of PAI-1
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0 Pain Relevance 0

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