INT246856

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 7.80
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (SPAG8) biological_process (SPAG8)
Anatomy Link Frequency
fat 2
liver 1
muscle 1
adipose tissue 1
SPAG8 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 287 98.96 Very High Very High Very High
cva 7 27.20 Quite Low
corticosteroid 21 5.00 Very Low Very Low Very Low
lidocaine 7 5.00 Very Low Very Low Very Low
local anesthetic 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 245 99.80 Very High Very High Very High
Diabetes Mellitus 105 99.04 Very High Very High Very High
Impaired Glucose Tolerance 301 98.96 Very High Very High Very High
Insulin Resistance 175 96.48 Very High Very High Very High
Abdominal Obesity 7 85.48 High High
Syndrome 7 82.56 Quite High
Hyperglycemia 7 52.20 Quite High
Polycystic Ovary Syndrome 35 32.68 Quite Low
Weight Loss 21 30.80 Quite Low
Hypertension 7 28.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-HSD1) is highly expressed in liver, adipose tissue, and muscle and generates the active glucocorticoid cortisol from inactive cortisone and therefore amplifies local glucocorticoid action (11).
Gene_expression (expressed) of HSD1 in liver associated with obesity
1) Confidence 0.75 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 1.37 Pain Relevance 0.13
-HSD1 expression in women may contribute to glucose intolerance.
Gene_expression (expression) of HSD1 associated with impaired glucose tolerance
2) Confidence 0.75 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551674 Disease Relevance 0.91 Pain Relevance 0.25
-HSD1 has been described in some studies (33) but not all (34).
Gene_expression (described) of HSD1
3) Confidence 0.65 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.74 Pain Relevance 0.11
-HSD1 expression was increased in patients with IGT and correlated with glucose levels across the OGTT (R = 0.44, P < 0.001) but was independent of fat mass.
Gene_expression (expression) of HSD1 in fat associated with tolerance
4) Confidence 0.58 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551674 Disease Relevance 1.20 Pain Relevance 0.36
-HSD1 expression was higher in those with IGT than in those with normal glucose tolerance (0.5 ± 0.06 vs. 0.29 ± 0.03 AU, P < 0.005), despite fat mass (total and regional) being similar between the two groups (Fig. 1A).
Gene_expression (expression) of HSD1 in fat associated with tolerance and impaired glucose tolerance
5) Confidence 0.58 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 0.84 Pain Relevance 0.29
-HSD1) is highly expressed in liver, adipose tissue, and muscle and generates the active glucocorticoid cortisol from inactive cortisone and therefore amplifies local glucocorticoid action (11).
Gene_expression (expressed) of HSD1 in muscle associated with obesity
6) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 1.37 Pain Relevance 0.13
-HSD1) is highly expressed in liver, adipose tissue, and muscle and generates the active glucocorticoid cortisol from inactive cortisone and therefore amplifies local glucocorticoid action (11).
Gene_expression (expressed) of HSD1 in adipose tissue associated with obesity
7) Confidence 0.26 Published 2008 Journal Diabetes Section Body Doc Link PMC2551674 Disease Relevance 1.37 Pain Relevance 0.13

General Comments

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