INT246938

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.88
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, Tlr2) plasma membrane (Tlr4, Tlr2) intracellular (Tlr4, Tlr2)
cytoplasm (Tlr4, Tlr2)
Tlr4 (Mus musculus)
Tlr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Taxol 2 98.76 Very High Very High Very High
Inflammation 52 94.32 High High
Inflammatory response 16 85.36 High High
chemokine 11 55.20 Quite High
ischemia 12 50.00 Quite Low
cytokine 24 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 212 96.80 Very High Very High Very High
Renal Disease 9 96.36 Very High Very High Very High
INFLAMMATION 69 94.32 High High
Infection 9 92.24 High High
Burns 222 78.12 Quite High
Ileus 4 62.68 Quite High
Cv Unclassified Under Development 12 50.00 Quite Low
Urological Neuroanatomy 32 5.00 Very Low Very Low Very Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Sepsis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR2 discriminates peptidoglycan (PGN), lipoprotein, lipoarabinomannan (LAM) and zymosan, whereas TLR4 recognizes lipopolysaccharide (LPS), lipoteichoic acid (LTA) and Taxol [11].
TLR4 Binding (recognizes) of TLR2 associated with taxol
1) Confidence 0.39 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.84 Pain Relevance 0.18
The ratio between the copy numbers of TLR2, TLR4 and GAPDH represented the normalized TLR2 and TLR4 levels for each sample and could be compared with those of other samples.
TLR4 Binding (represented) of TLR2
2) Confidence 0.35 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0 Pain Relevance 0
As TLR4 can recognize other endogenous ligands than TLR2 [21], can use an alternative signaling cascade [22] and does not hybridize with other TLR family members as TLR2 does, the functional significance of TLR4 during tissue injury could be different from TLR2.
TLR4 Binding (recognize) of TLR2 associated with injury
3) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570789 Disease Relevance 1.19 Pain Relevance 0.10
TLR2 discriminates peptidoglycan (PGN), lipoprotein, lipoarabinomannan (LAM) and zymosan, whereas TLR4 recognizes lipopolysaccharide (LPS), lipoteichoic acid (LTA) and Taxol [11].
LPS Binding (recognizes) of TLR2 associated with taxol
4) Confidence 0.26 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.85 Pain Relevance 0.18

General Comments

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