INT246978

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.62
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTPLA) lyase activity (PTPLA) endoplasmic reticulum (PTPLA)
PTPLA (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 335 100.00 Very High Very High Very High
agonist 25 94.88 High High
Trigeminal ganglion neurons 2 65.04 Quite High
Neuropathic pain 1 20.16 Low Low
Pain 22 5.00 Very Low Very Low Very Low
nociceptor 7 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
trigeminal ganglion 4 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Testicular Cancer 16 98.52 Very High Very High Very High
Seminoma 12 94.80 High High
Carcinoma In Situ 12 94.28 High High
Apoptosis 105 89.68 High High
Cancer 27 89.68 High High
Disease 24 88.24 High High
Death 14 82.40 Quite High
Heat Stress Disorders 4 82.08 Quite High
Ganglion Cysts 8 64.16 Quite High
Neuropathic Pain 2 20.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many of the acute cellular effects associated with CAP occur via the interaction of CAP and TRPV1.
CAP Binding (interaction) of associated with qutenza
1) Confidence 0.18 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2588595 Disease Relevance 1.25 Pain Relevance 0.65
This section illustrates these issues and critically discusses how CAP can be affected by employing diverse approaches.
CAP Binding (affected) of
2) Confidence 0.15 Published 2008 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2553058 Disease Relevance 0 Pain Relevance 0
Many of the acute cellular effects associated with CAP occur via the interaction of CAP and TRPV1.
CAP Binding (associated) of associated with qutenza
3) Confidence 0.14 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2588595 Disease Relevance 1.26 Pain Relevance 0.66
With increasing CAP concentrations, the effect was even more pronounced with both cell lines, and after either both 24 and 48 h (Fig. 3A and 3B).
CAP Binding (concentrations) of associated with qutenza
4) Confidence 0.12 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2588595 Disease Relevance 0.51 Pain Relevance 0.68
In fact, previous findings have indicated that concentrations of CAP in the range of 100 to 300 ?
CAP Binding (concentrations) of associated with qutenza
5) Confidence 0.12 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2588595 Disease Relevance 0.49 Pain Relevance 0.47
All together, this means that RTX has a broader therapeutic window than CAP, making it a more desirable candidate for human clinical application.
CAP Binding (window) of associated with qutenza
6) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.12 Pain Relevance 0.33

General Comments

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