INT247021

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.91
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GJA1) Golgi apparatus (GJA1) endoplasmic reticulum (GJA1)
cell-cell signaling (GJA1) cytoplasm (GJA1) signal transducer activity (GJA1)
Anatomy Link Frequency
myocytes 1
GJA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 22 99.98 Very High Very High Very High
Kinase C 5 93.12 High High
Dismenorea 20 5.00 Very Low Very Low Very Low
Action potential 11 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
nav1.3 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 19 99.98 Very High Very High Very High
Disease 9 82.96 Quite High
Hypertrophy 6 74.44 Quite High
Endometriosis (extended) 5 72.20 Quite High
Heart Arrhythmia 16 61.20 Quite High
Aging 10 57.88 Quite High
Arrhythmias 2 Under Development 27 56.16 Quite High
Overactive Bladder 5 27.52 Quite Low
Congenital Anomalies 1 23.36 Low Low
Apoptosis 1 11.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all biopsies from pregnant women in labour or prior to labour, the antibody for unphosphorylated connexin 43 did not bind to the smooth myocytes.
connexin 43 Neg (not) Binding (bind) of in myocytes
1) Confidence 0.47 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
The antibody we used specifically binds to connexin 43 only when this particular serine is unphosphorylated.
connexin 43 Binding (binds) of
2) Confidence 0.47 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0.05
The appearance, number and location of the cells that we identified by staining for unphosphorylated connexin 43 and c-kit correspond most probably with MICs.
connexin 43 Binding (staining) of
3) Confidence 0.36 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
Indeed, the presence of large areas of fibrosis associated with connexin-43 redistribution in areas surrounding fibrosis [11] most likely contributes to the occurrence of reentrant arrhythmias.
connexin-43 Binding (associated) of associated with fibrosis
4) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.76 Pain Relevance 0.18
This indicates that the cells that bind unphosphorylated connexin 43 are likely to be MICs.
connexin 43 Binding (bind) of
5) Confidence 0.35 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0 Pain Relevance 0
Immunofluorescence provides crisp clear images for a more precise localisation of bound antigens and was used to confirm the homogenous pattern of binding of unphosphorylated connexin 43 found with the HRP method.
connexin 43 Binding (binding) of
6) Confidence 0.35 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2553078 Disease Relevance 0.15 Pain Relevance 0

General Comments

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