INT247099

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 9.21
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PTBP1) mRNA processing (PTBP1) nucleolus (PTBP1)
RNA binding (PTBP1) nucleus (PTBP1)
Anatomy Link Frequency
lung 1
PTBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 75.00 Quite High
Angina 8 68.00 Quite High
cocaine 2 65.56 Quite High
cva 15 51.60 Quite High
agonist 16 49.68 Quite Low
antagonist 3 25.00 Low Low
headache 5 9.56 Low Low
withdrawal 18 5.00 Very Low Very Low Very Low
Pain 17 5.00 Very Low Very Low Very Low
cytokine 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 460 100.00 Very High Very High Very High
Premature Birth 209 100.00 Very High Very High Very High
Disease 174 100.00 Very High Very High Very High
Pre-term Labor 91 99.66 Very High Very High Very High
Nicotine Addiction 76 96.20 Very High Very High Very High
Starvation 12 94.96 High High
Cough 28 92.64 High High
Schistosomiasis Haematobia 4 90.80 High High
Diarrhoea 7 89.68 High High
Malaria 4 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After assessing normality to the score using histogram, the composite score was dichotomized using mean as a cut-off value so that higher value coded as 1 showing higher overall knowledge of PTB in this community
Positive_regulation (knowledge) of PTB associated with mycobacterial infection
1) Confidence 0.50 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2867998 Disease Relevance 1.45 Pain Relevance 0.07
Most of the men and women discussants from both kebeles believed that dust deposits in the lung can result in PTB.
Positive_regulation (result) of PTB in lung associated with mycobacterial infection
2) Confidence 0.47 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2867998 Disease Relevance 1.38 Pain Relevance 0
The discussants also suggested these same factors as the cause of PTB.
Positive_regulation (cause) of PTB associated with mycobacterial infection
3) Confidence 0.47 Published 2010 Journal BMC Public Health Section Abstract Doc Link PMC2867998 Disease Relevance 1.38 Pain Relevance 0
But, a male participant from Hanekisna-Arado said that "If dust could cause PTB, all persons who are involved in lorry driving and road construction would suffer from it."
Positive_regulation (cause) of PTB associated with mycobacterial infection
4) Confidence 0.47 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2867998 Disease Relevance 1.39 Pain Relevance 0
Premature delivery, defined as birth prior to 37 weeks, remains one of the major problems that lead to perinatal morbidity and mortality in the developed countries.1 It affects approximately 12.5% of all deliveries in the US; one third of these occur before 34 weeksÂ’ gestation.2,3 These numbers reflect an increase of 30% over the preterm birth (PTB) rate reported in 19813 and equates to nearly 500,000 PTBs each year.
Positive_regulation (increase) of PTB associated with premature birth
5) Confidence 0.29 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 0.46 Pain Relevance 0
As shown in Figure 1B, the reduction in the number of cells staining positively for DENV E protein with increasing concentrations of siRNA specific for PTB when compared with cells reverse-transfected with the scrambled sequence of PTB siRNA or mock-transfected cells.
Positive_regulation (increasing) of PTB
6) Confidence 0.29 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.46 Pain Relevance 0
The PTB rate for black women is almost twice that for white women of comparable age in the USA irrespective of socioeconomic status.36 This racial gap has slightly diminished during the past 10 years largely due to an increase in PTD rates for white infants;36 although PTB rates have increased by 3.6% in black women (from 15.5% in 1975 to 16% in 1995), a rise of 22.3% in white women (6.9% to 8.4%) has been reported over the same interval.37 In black primigravid women in USA, rates of PTD increased from 1975 to 1990 and began to decline thereafter, whereas among white primigravid women, the rates rose between 1975 and 1995.38 Why this difference exists is not clear, but since the preponderance of preterm deliveries in the black population arose in the idiopathic PTL group, it can not be explained by variation in socio-economic status and hence is suggestive of a biological variation.


Positive_regulation (increased) of PTB associated with premature birth and pre-term labor
7) Confidence 0.23 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697509 Disease Relevance 0.95 Pain Relevance 0.03
PTB is a complex disease, potentially induced by several etiologic factors from multiple pathophysiologic pathways.
Positive_regulation (induced) of PTB associated with disease
8) Confidence 0.23 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2553267 Disease Relevance 0.40 Pain Relevance 0.06
PTL is the most common event leading to PTB, but the prevention of SPTL remains challenging for clinicians.
Positive_regulation (leading) of PTB associated with pre-term labor
9) Confidence 0.14 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.55 Pain Relevance 0
Compared to traditional clinical methods, the combination of TVUSS and FFN may identify women who are in SPTL, and who are at increased risk of PTB, but further research is needed to identify factors that have better positive predictive values.
Positive_regulation (increased) of PTB associated with pre-term labor
10) Confidence 0.13 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2861440 Disease Relevance 0.80 Pain Relevance 0

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