INT247102

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 14.18
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MBL2) extracellular region (MBL2)
Anatomy Link Frequency
plasma 2
neutrophils 2
MBL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 290 99.52 Very High Very High Very High
antagonist 8 99.22 Very High Very High Very High
Inflammation 129 92.36 High High
Antihistamine 5 85.68 High High
cytokine 49 82.76 Quite High
Inflammatory response 10 71.52 Quite High
chemokine 15 68.84 Quite High
abdominal pain 5 51.20 Quite High
agonist 33 50.00 Quite Low
cva 20 48.40 Quite Low
Disease Link Frequency Relevance Heat
Bacterial Meningitis 5 99.96 Very High Very High Very High
Pancreatic Cancer 49 99.92 Very High Very High Very High
Candida Infection 5 99.80 Very High Very High Very High
Stress 13 99.64 Very High Very High Very High
Hypersensitivity 6 99.60 Very High Very High Very High
Dyspepsia 290 99.52 Very High Very High Very High
Flavivirus Infection 320 99.42 Very High Very High Very High
Dengue 437 99.04 Very High Very High Very High
Inflammatory Bowel Disease 10 98.88 Very High Very High Very High
Gastritis 20 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LP is initiated by the mannose-binding lectins (MBL) that bind to complex carbohydrate residues on the surface of pathogens.
MBL Binding (bind) of
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.53 Pain Relevance 0.04
RII), interleukin-4 (IL-4), interleukin-1 receptor antagonist (IL-1RA), and mannose-binding lectin (MBL) were investigated in Vietnamese [12].
MBL Binding (investigated) of associated with antagonist
2) Confidence 0.36 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.28 Pain Relevance 0.08
MBL has been shown to have a strong binding affinity for Candida albicans and acts in first-line defense against this organism, increasing C3 deposition on its surface and hence phagocytosis by neutrophils [32,33].
MBL Binding (affinity) of in neutrophils associated with candida infection
3) Confidence 0.35 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.78 Pain Relevance 0
The activity of the LP was evaluated by measuring the levels of oligomerized MBL, and a significant increase of MBL oligomerization was found in the DHF patients as compared to the DF patients during the acute phase of infection, which might have contributed to the elevated C4a level.
MBL Binding (oligomerization) of associated with flavivirus infection, dengue and infection
4) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.48 Pain Relevance 0
The MBL-MASP complex has a significant role in increasing C3b deposition on the surface of S. aureus [22], contributing to an increase in its engulfment by neutrophils.
MBL Binding (complex) of in neutrophils
5) Confidence 0.31 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.49 Pain Relevance 0.06
The A allele is also termed "wild-type" and is usually associated with normal MBL levels.
MBL Binding (associated) of
6) Confidence 0.31 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.05 Pain Relevance 0
In the case of pneumococcus, MBL has an ancillary part in promoting opsonophagocytosis, and low serum levels have been associated with increased mortality [19].
MBL Binding (associated) of associated with bacterial meningitis
7) Confidence 0.31 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.51 Pain Relevance 0.04
Recent reports have identified a mutation in exon 3 of this gene leading to the exchange of aspartate with glycine at position 105 (D105G) within the CUB1 domain, causing impaired binding to MBL, and also low circulating plasma levels of MASP-2 [11,12].
MBL Binding (binding) of in plasma
8) Confidence 0.29 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.07 Pain Relevance 0.03
MBL2 is a calcium-dependent serum protein that plays a role in the innate immune response by binding to carbohydrates on the surface of a wide range of pathogens including viruses, bacteria, fungi, and protozoa where it can activate the complement system or act directly as an opsonin [17,18].
MBL2 Binding (binding) of
9) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2906412 Disease Relevance 0.84 Pain Relevance 0
The increased complement activation in DHF patients is correlated with MBL oligomerization, but not correlated with levels of immune complexes, C1q or CRP
MBL Binding (oligomerization) of associated with flavivirus infection
10) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.38 Pain Relevance 0
In order to identify the mechanism of the CP or LP activation we measured levels of C1q, CRP, CIC-C1q and oligomerized MBL in plasma samples from DF and DHF patients (Figure 4; Table 2).
MBL Binding (oligomerized) of in plasma associated with flavivirus infection and dengue
11) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.49 Pain Relevance 0
Two other genes upstream and downstream of this branch did not associate (soluble mannose-binding lectin (protein C) 2 (MBL2) and factor II [FII]).
MBL2 Neg (not) Binding (associate) of
12) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.37 Pain Relevance 0.14
Two other genes upstream and downstream of this branch did not associate (soluble mannose-binding lectin (protein C) 2 (MBL2) and factor II [FII]).
MBL2 Binding (binding) of
13) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0.37 Pain Relevance 0.14
Furthermore, two recent studies of possible association of MBL2 haplotype and the susceptibility of H. pylori infection as well as the risk of gastric cancer were reported [27, 28].
MBL2 Binding (association) of associated with stomach cancer and infection
14) Confidence 0.20 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 0.62 Pain Relevance 0.09
Genotyping for TLR2 and MBL genes
MBL Binding (Genotyping) of
15) Confidence 0.20 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 0.42 Pain Relevance 0
M TRO, only two genes involved in oxidative stress, namely, mannose binding lectin 2 (MBL2) and serum/glucocorticoid regulated kinase 2 (SGK2), were induced.
MBL2 Binding (binding) of associated with stress
16) Confidence 0.17 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.10 Pain Relevance 0
We have also shown that MBL2 codon54 G/A (G54D) are also associated with certain phenotypes of ulcerative colitis [33].
MBL2 Binding (associated) of associated with inflammatory bowel disease
17) Confidence 0.15 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 0.91 Pain Relevance 0.16
We aimed to clarify the association between common polymorphisms of TLR2 and MBL2 genes with FD in Japanese subjects.
MBL2 Binding (association) of associated with nud
18) Confidence 0.15 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2966931 Disease Relevance 0.94 Pain Relevance 0.43
However, we did not find any association between MBL2 genotypes and FD.
MBL2 Neg (not) Binding (association) of associated with nud
19) Confidence 0.15 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966931 Disease Relevance 1.19 Pain Relevance 0.32
MBL concentration, MBL/MASP-2 complex activity, and C4 concentration
MBL Binding (activity) of
20) Confidence 0.04 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2734250 Disease Relevance 0.34 Pain Relevance 0

General Comments

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