INT247118

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.15
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MPZ) plasma membrane (MPZ)
Anatomy Link Frequency
lymphocyte 2
Schwann cells 2
T cell 2
MPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 99.54 Very High Very High Very High
gABA 69 99.36 Very High Very High Very High
Sciatic nerve 2 98.68 Very High Very High Very High
c fibre 42 95.04 Very High Very High Very High
dorsal root ganglion 13 90.56 High High
unmyelinated 38 77.72 Quite High
Inflammation 81 73.52 Quite High
GABA receptor 1 70.36 Quite High
cytokine 10 45.80 Quite Low
Central nervous system 3 44.32 Quite Low
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 344 100.00 Very High Very High Very High
Dengue 109 100.00 Very High Very High Very High
Death 4 96.00 Very High Very High Very High
Ganglion Cysts 13 90.56 High High
Disease 55 90.12 High High
Infection 70 88.00 High High
INFLAMMATION 92 73.52 Quite High
Neuropathic Pain 4 47.96 Quite Low
Virus Diseases 1 25.00 Low Low
Nociception 8 18.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since lymphocyte counts did not differ between the DF, DHF and DSS children (p?
Neg (not) Regulation (differ) of Gene_expression (children) of DSS in lymphocyte associated with dengue and dengue hemorrhagic fever
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.15 Pain Relevance 0.04
However both GABAA and GABAB receptors have been immunohistochemically identified in cultured Schwann cells from rat [30] and segments of rat sciatic nerve [31] and their activation by GABA agonists has been suggested to influence the expression of myelin proteins P0 and PMP22 [30].
Regulation (influence) of Gene_expression (expression) of myelin proteins P0 in Schwann cells associated with gaba, agonist and sciatic nerve
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.51 Pain Relevance 0.83
Protective and/or pathogenic T cell immunity is supposed to be important in the pathogenesis of DHF and DSS.


Regulation (important) of Gene_expression (pathogenesis) of DSS in T cell associated with dengue hemorrhagic fever
3) Confidence 0.02 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2553281 Disease Relevance 1.49 Pain Relevance 0

General Comments

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