INT24712

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Context Info
Confidence 0.54
First Reported 1985
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 8.58
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ap3d1) transport (Ap3d1) vesicle-mediated transport (Ap3d1)
Golgi apparatus (Ap3d1) cytoplasm (Ap3d1)
Anatomy Link Frequency
brain 2
neuronal 1
blood 1
telencephalon 1
cerebral cortex 1
Ap3d1 (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 14 99.50 Very High Very High Very High
midbrain 11 98.56 Very High Very High Very High
narcan 4 98.56 Very High Very High Very High
halothane 60 98.48 Very High Very High Very High
Morphine 14 97.84 Very High Very High Very High
cerebral cortex 21 97.64 Very High Very High Very High
anesthesia 100 92.80 High High
iatrogenic 8 92.72 High High
Spinal cord 11 87.88 High High
Inflammation 17 77.72 Quite High
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 676 100.00 Very High Very High Very High
Infection 53 99.40 Very High Very High Very High
Shock 8 98.52 Very High Very High Very High
Togavirus Infection 75 96.84 Very High Very High Very High
Apoptosis 16 96.72 Very High Very High Very High
Disease 41 95.96 Very High Very High Very High
Heat Stroke 20 95.72 Very High Very High Very High
Congenital Anomalies 12 95.56 Very High Very High Very High
Stress 48 95.40 Very High Very High Very High
Fever 64 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MHC class I receptors such as Cd1d1, B2m and Ap3d1 were also upregulated at 96 hr post infection.
Positive_regulation (upregulated) of Ap3d1 associated with infection
1) Confidence 0.54 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.93 Pain Relevance 0.13
The exposure of rats to tail pinch increased the t-MH level in the telencephalon and the midbrain.
Positive_regulation (increased) of t-MH in telencephalon associated with midbrain
2) Confidence 0.28 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2470944 Disease Relevance 0.32 Pain Relevance 0.05
-induced accumulation of t-MH and this effect was antagonized by naloxone.
Positive_regulation (accumulation) of t-MH associated with narcan
3) Confidence 0.22 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4031857 Disease Relevance 0 Pain Relevance 0.76
Other types of noxious stimuli, such as placing mice on a hot plate or subjecting mice to acetic acid-induced writhing, also significantly elevated the level of t-MH but not that of HA in the mouse brain.
Positive_regulation (elevated) of t-MH in brain
4) Confidence 0.20 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2470944 Disease Relevance 0.30 Pain Relevance 0.05
The HA turnover, measured either by the accumulation of t-MH after pargyline injection or by the HA depletion after the treatment with alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase, was enhanced by the exposure to tail pinch, like the enhancement produced by the exposure to foot shock.
Positive_regulation (accumulation) of t-MH in tail associated with shock
5) Confidence 0.16 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2470944 Disease Relevance 0.34 Pain Relevance 0.04
In mice, the exposure to tail pinch markedly increased the brain level of tele-methylhistamine (t-MH), a predominant metabolite of brain HA, while the level of HA was not changed.
Positive_regulation (increased) of t-MH in brain
6) Confidence 0.16 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2470944 Disease Relevance 0.33 Pain Relevance 0.03
-induced accumulation of t-MH and this effect was antagonized by naloxone.
Positive_regulation (-induced) of t-MH associated with narcan
7) Confidence 0.16 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4031857 Disease Relevance 0 Pain Relevance 0.76
Perhaps the most convincing, though unfortunate, episode of exercise induced MH was reported by Tobin et al., a fatal episode in a 13-year-old boy who had experienced a clinical episode of MH and developed signs of MH following exercise some months later.
Positive_regulation (induced) of MH associated with malignant hyperthermia
8) Confidence 0.06 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.79 Pain Relevance 0.09
Hence, a high index of suspicion for these disorders as well as the ability to measure ETCO2 and obtain arterial and venous blood gas analysis is essential in order to differentiate MH from these disorders.
Positive_regulation (differentiate) of MH in blood associated with malignant hyperthermia
9) Confidence 0.06 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.25 Pain Relevance 0.38
Malignant hyperthermia (MH) is a hypermetabolic response to potent inhalation agents (such as halothane, sevoflurane, desflurane), the depolarizing muscle relaxant succinylcholine, and rarely, in humans, to stresses such as vigorous exercise and heat.
Positive_regulation (response) of MH in muscle associated with stress, halothane and malignant hyperthermia
10) Confidence 0.06 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.25 Pain Relevance 0.11
Numerous factors could be involved in triggering MH – age, type of anesthetic, environmental temperature, mitigating drugs administered simultaneously, and degree of stress [3].
Positive_regulation (triggering) of MH associated with stress and malignant hyperthermia
11) Confidence 0.06 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.82 Pain Relevance 0.13
Central infusion of TRH increased the concentration of histamine in the TMN (p < 0.01 versus control; Fig. 4a) and increased the pargyline-induced accumulation of t-MH in the TMN, VMH, and PVN in rats (p < 0.05 versus control; Fig. 4b).


Positive_regulation (accumulation) of t-MH
12) Confidence 0.01 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.13 Pain Relevance 0
Moreover, microinfusion of TRH into the TMN increased HDC activity and t-MH content in the TMN.
Positive_regulation (increased) of t-MH
13) Confidence 0.01 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0 Pain Relevance 0.03
Pre-treatment with pargyline, an inhibitor of monoamine oxidase B, is useful for this assessment, as it induces the accumulation of t-MH in the extraneuronal space (Oishi et al. 1987; Oohara et al. 1994, 1994).
Positive_regulation (accumulation) of t-MH associated with monoamine
14) Confidence 0.01 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0 Pain Relevance 0.05
As shown in Fig. 1b and c, the central infusion of TRH at 100 and 500 nmol doses increased histamine and t-MH contents in the TMN but not at 10 nmol of TRH (Fig. 1b and c).
Positive_regulation (increased) of t-MH
15) Confidence 0.01 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.05 Pain Relevance 0
Moreover, histamine and t-MH contents were also increased in a dose-dependent manner (Fig. 1b and c).


Positive_regulation (increased) of t-MH
16) Confidence 0.01 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.07 Pain Relevance 0
Rats were pre-treated with pargyline hydrochloride (0.33 mmol/kg, i.p.), an inhibitor of monoamine oxidase B which induced accumulation of tete-methylhistamine (t-MH) in the extraneural space as a major metabolite of released neuronal histamine 90 min before the central infusion of either TRH (100 nmol/10 ?
Positive_regulation (accumulation) of t-MH in neuronal associated with monoamine
17) Confidence 0.01 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0 Pain Relevance 0.05
Microinfusion of TRH into the TMN increased the t-MH content in TMN of the hypothalamus, but not in the AH and cerebral cortex, compared with PBS infusion (p < 0.05; Fig. 6a).
Neg (not) Positive_regulation (increased) of t-MH in cerebral cortex associated with cerebral cortex
18) Confidence 0.01 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0 Pain Relevance 0.05

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