INT247120

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.13
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MPZ) plasma membrane (MPZ)
Anatomy Link Frequency
neutrophils 2
MPZ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 80 95.24 Very High Very High Very High
antagonist 2 93.64 High High
rheumatoid arthritis 1 81.20 Quite High
Inflammatory mediators 4 70.72 Quite High
cytokine 11 64.76 Quite High
cva 8 43.60 Quite Low
headache 2 16.64 Low Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 483 100.00 Very High Very High Very High
Pleural Effusion 6 98.28 Very High Very High Very High
Pressure Volume 2 Under Development 5 98.20 Very High Very High Very High
Pressure And Volume Under Development 4 97.44 Very High Very High Very High
Heart Rate Under Development 2 97.44 Very High Very High Very High
INFLAMMATION 90 95.24 Very High Very High Very High
Adhesions 1 93.92 High High
Infection 111 88.96 High High
Dengue 130 88.56 High High
Thrombocytopenia 10 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A putative neutrophil origin of this gene expression pattern is however supported by the over-expression in DSS patients blood cells of transcripts encoding other neutrophil-related molecules such as the MMP8 matrix metalloprotease, CEACAM-6, CEACAM-8 and CD99L2 adhesion molecules (Tables 4 and S2) involved in the recruitment of neutrophils to vascular endothelia.
Positive_regulation (supported) of Gene_expression (expression) of DSS in neutrophils associated with dengue hemorrhagic fever and adhesions
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.24 Pain Relevance 0.25
Among them, the T allele at position 352 of the VDR gene was associated with resistance to DSS as well as homozygotes for the arginine variant at position 131 of the Fc?
Positive_regulation (homozygotes) of Gene_expression (resistance) of DSS associated with dengue hemorrhagic fever
2) Confidence 0.04 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.20 Pain Relevance 0.08
The DSS classification required DHF manifestation plus evidence of clinical hypovolemic shock (tachycardia and narrow pulse pressure (<20 mmHg))
Positive_regulation (required) of Gene_expression (classification) of DSS associated with heart rate under development, pressure volume 2 under development and dengue hemorrhagic fever
3) Confidence 0.04 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.69 Pain Relevance 0

General Comments

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