INT24715

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Context Info
Confidence 0.38
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.90
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF3) extracellular region (CSF3) enzyme binding (CSF3)
Anatomy Link Frequency
granulocyte 2
CSF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 99.92 Very High Very High Very High
Paracetamol 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neutropenia 2 99.84 Very High Very High Very High
Agranulocytosis 4 98.24 Very High Very High Very High
Disease 1 86.56 High High
Body Weight 3 81.04 Quite High
Congenital Anomalies 6 74.00 Quite High
Pain 3 55.64 Quite High
Splenomegaly 1 55.40 Quite High
Infection 1 45.12 Quite Low
Low Back Pain 4 5.00 Very Low Very Low Very Low
Headache 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of recombinant human granulocyte colony-stimulating factor on neutropenia in patients with congenital agranulocytosis.
Regulation (Effects) of granulocyte colony-stimulating factor in granulocyte associated with agranulocytosis and neutropenia
1) Confidence 0.38 Published 1989 Journal N. Engl. J. Med. Section Title Doc Link 2471075 Disease Relevance 0.75 Pain Relevance 0.06
The effects of daily recombinant human granulocyte colony-stimulating factor administration on normal granulocyte donors undergoing leukapheresis.
Regulation (effects) of granulocyte colony-stimulating factor in granulocyte associated with pain
2) Confidence 0.35 Published 1993 Journal Blood Section Title Doc Link 7681705 Disease Relevance 0 Pain Relevance 0.10
This effect could have confounded the PK data, and it is therefore unsurprising that the bioequivalence of Hospira filgrastim and Amgen filgrastim was not demonstrated by all PK parameters.
Neg (not) Regulation (demonstrated) of filgrastim
3) Confidence 0.04 Published 2010 Journal Ann Hematol Section Body Doc Link PMC2924967 Disease Relevance 0.07 Pain Relevance 0
This effect could have confounded the PK data, and it is therefore unsurprising that the bioequivalence of Hospira filgrastim and Amgen filgrastim was not demonstrated by all PK parameters.
Neg (not) Regulation (demonstrated) of filgrastim
4) Confidence 0.04 Published 2010 Journal Ann Hematol Section Body Doc Link PMC2924967 Disease Relevance 0.07 Pain Relevance 0

General Comments

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