INT247157

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Il12a) signal transducer activity (Tas2r129) signal transduction (Tas2r129)
extracellular space (Il12a) extracellular region (Il12a) molecular_function (Tas2r129)
Anatomy Link Frequency
Th1 cell 2
peritoneal macrophages 2
Tas2r129 (Mus musculus)
Il12a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 16 99.32 Very High Very High Very High
Inflammation 2 28.88 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Granuloma 14 92.88 High High
Schistosomiasis 50 89.20 High High
Infection 16 86.24 High High
Targeted Disruption 2 82.44 Quite High
Immunization 28 74.04 Quite High
Helminth Infection 78 67.56 Quite High
INFLAMMATION 2 28.88 Quite Low
Disease 8 11.20 Low Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, rSm29 has stimulated peritoneal macrophages from C57BL/6 (2016±423 pg/ml) or TLR4 KO (1108±197 pg/ml) mice to produce IL-12 (Fig. 4).
rSm29 Positive_regulation (stimulated) of Gene_expression (produce) of IL-12 in peritoneal macrophages
1) Confidence 0.00 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553283 Disease Relevance 0.41 Pain Relevance 0.05
In TLR4 KO mice, rSm29 has induced the production of large amounts of IL-12 that is the key cytokine involved in Th1 cell development.
rSm29 Positive_regulation (induced) of Gene_expression (production) of IL-12 in Th1 cell associated with cytokine
2) Confidence 0.00 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553283 Disease Relevance 0.82 Pain Relevance 0.08

General Comments

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