INT24724

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Context Info
Confidence 0.67
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.51
Pain Relevance 6.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
plasma 2
CSF 2
nerve 2
neurons 2
salivary gland epithelium 2
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 167 100.00 Very High Very High Very High
Neuropeptide 21 100.00 Very High Very High Very High
Migraine 14 100.00 Very High Very High Very High
headache 7 100.00 Very High Very High Very High
substance P 6 100.00 Very High Very High Very High
Clonidine 3 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
imagery 45 99.80 Very High Very High Very High
central sensitization 1 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 20 100.00 Very High Very High Very High
Obesity 7 100.00 Very High Very High Very High
Metastasis 52 99.44 Very High Very High Very High
Carcinoid 106 99.28 Very High Very High Very High
Gastrinoma 14 99.04 Very High Very High Very High
Adenocarcinoma 4 97.32 Very High Very High Very High
Sleep Disorders 10 96.66 Very High Very High Very High
Cancer 198 96.48 Very High Very High Very High
Fibromyalgia 6 95.88 Very High Very High Very High
Hypoglycemia 6 91.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased concentrations of somatostatin, produced by pancreatic D cells or by intestinal mucosa, inihibit secretion of a number of GIT hormones, endocrine and exocrine pancreatic secretion.
Positive_regulation (Increased) of Gene_expression (produced) of somatostatin in pancreatic D cells associated with somatostatin
1) Confidence 0.67 Published 2007 Journal Rozhl Chir Section Abstract Doc Link 18303777 Disease Relevance 1.12 Pain Relevance 0.17
Neuropeptide expression is plastic; during development, neurons that switch from a noradrenergic to a cholinergic phenotype increase expression of vasoactive intestinal polypeptide, somatostatin, and substance P.
Positive_regulation (increase) of Gene_expression (expression) of somatostatin in neurons associated with somatostatin, neuropeptide and substance p
2) Confidence 0.49 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 8024263 Disease Relevance 0.23 Pain Relevance 0.78
The co-existence of pituitary hormone and neuropeptide secretion, such as growth hormone, prolactin, adrenocorticotropic hormone, thyroid stimulating hormone, triiodothyronine, somatostatin, oxytocin, follicle stimulating hormone, luteinizing hormone, arginine vasopressin, growth hormone releasing hormone, corticotropin releasing hormone, nerve growth factor, vasoactive intestinal peptide, (pro) enkephalin, and beta-endorphin, production of a number of interleukins and growth factors, as well as the expression of receptors for all, by the same RE cell is an unique molecular biological phenomenon.
Positive_regulation (stimulating) of Gene_expression (production) of somatostatin in nerve associated with nerve growth factor, somatostatin, neuropeptide and enkephalin
3) Confidence 0.49 Published 1999 Journal In Vivo Section Abstract Doc Link 10459506 Disease Relevance 0 Pain Relevance 0.29
Several study conducted on pancreatic adenocarcinoma animal models demonstrated that intratumoural SSTR 2 gene transfer (using polyethylenimine synthetic vector) inhibited intratumoural production of somatostatin that was critical for the SSTR 2 antitumoral effect.
Positive_regulation (critical) of Gene_expression (production) of somatostatin associated with adenocarcinoma and somatostatin
4) Confidence 0.38 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.93 Pain Relevance 0.16
In addition, expression of some neuropeptides such as vasoactive intestinal polypeptide (VIP), somatostatin (SRIF), and substance P in the human salivary gland epithelium during the gestational period was observed, whereas the other polypeptides examined, including glucagon, cholecystokinin (CCK), Leu-enkephalin, and calcitonin were absent.
Positive_regulation (observed) of Gene_expression (expression) of somatostatin in salivary gland epithelium associated with somatostatin, neuropeptide, enkephalin, cholecystokinin and substance p
5) Confidence 0.19 Published 1989 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2471726 Disease Relevance 0.07 Pain Relevance 0.41
Based on experimental findings, it can be postulated that reduced CSF levels of GDNF and somatostatin in both CM and PCM + PAAH patients can contribute to sustained central sensitization underlying chronic head pain.
Positive_regulation (contribute) of Gene_expression (levels) of somatostatin in CSF associated with central sensitization, migraine, somatostatin and headache
6) Confidence 0.11 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16556241 Disease Relevance 2.09 Pain Relevance 2.58
The overexpression of somatostatin receptors and the presence of amine uptake and storage mechanisms allows targeted molecular imaging of NETs using somatostatin receptor scintigraphy (SRS) and metaiodobenzylguanidine (MIBG), respectively.
Positive_regulation (overexpression) of Gene_expression (overexpression) of somatostatin associated with somatostatin and imagery
7) Confidence 0.07 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 0.43 Pain Relevance 0.26
Interferon alfa upregulates the expression of somatostatin receptors, and somatostatin analogues reduce the side effects of interferon alfa 3,43.

6.4.3 Cytotoxic Treatment

Positive_regulation (upregulates) of Gene_expression (expression) of somatostatin associated with somatostatin
8) Confidence 0.03 Published 2006 Journal Current Oncology Section Body Doc Link PMC1891174 Disease Relevance 0.95 Pain Relevance 0.30
Growth hormone response to growth hormone-releasing hormone (GHRH), insulin, clonidine and arginine after GHRH pretreatment in obese children: evidence of somatostatin increase?
Positive_regulation (response) of Gene_expression (evidence) of somatostatin associated with obesity, somatostatin and clonidine
9) Confidence 0.02 Published 1995 Journal Eur. J. Endocrinol. Section Title Doc Link 7788012 Disease Relevance 0.57 Pain Relevance 0.31
Thirteen female patients suffering from fibromyalgia (FM) and thirteen female age-matched controls were intravenously injected with a bolus dose of 100 microg corticotropin-releasing hormone (CRH), and the evoked secretion pattern of ACTH, cortisol, somatostatin, and growth hormone (GH) was followed up for two hours, together with the plasma levels of CRH.
Positive_regulation (followed) of Gene_expression (pattern) of somatostatin in plasma associated with somatostatin and fibrositis
10) Confidence 0.02 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114308 Disease Relevance 0.57 Pain Relevance 0.44
The in vivo stability of this dextran-conjugated derivative, somatostatin-D70, was confirmed previously in animal studies, and the nanomolar "panaffinity" has been shown in in vitro receptor binding studies on cell lines transfected with the somatostatin receptor genes.
Positive_regulation (transfected) of Gene_expression (transfected) of somatostatin-D70 associated with somatostatin
11) Confidence 0.01 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15650261 Disease Relevance 0.56 Pain Relevance 0.41

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