INT247255

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Context Info
Confidence 0.30
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sgk1) endoplasmic reticulum (Sgk1) plasma membrane (Sgk1)
nucleus (Sgk1) response to stress (Sgk1) cytoplasm (Sgk1)
Anatomy Link Frequency
joint 2
Sgk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 33 99.20 Very High Very High Very High
IPN 5 98.48 Very High Very High Very High
Inflammation 17 97.90 Very High Very High Very High
Serotonin 6 92.04 High High
Arthritis 1 79.44 Quite High
Pain 16 77.60 Quite High
central sensitization 6 53.80 Quite High
Dynorphin 1 26.40 Quite Low
bradykinin 1 20.64 Low Low
intrathecal 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Inflammatory Pain 5 98.48 Very High Very High Very High
Arthritis 3 97.90 Very High Very High Very High
Targeted Disruption 1 93.84 High High
INFLAMMATION 15 85.52 High High
Hypersensitivity 3 77.96 Quite High
Pain 16 77.60 Quite High
Nociception 2 23.40 Low Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously reported that, after induction of peripheral joint inflammation, MeCP2 was phosphorylated in rat superficial dorsal horn and lamina I/III projection neurones, and that expression of SGK1, a protein under transcriptional repression by MeCP2, also expressed in lamina I/III projection neurones, increased in the superficial dorsal horn in an inflammatory pain state [7].
Positive_regulation (increased) of Gene_expression (expression) of SGK1 in joint associated with inflammation, ipn, repression, dorsal horn and arthritis
1) Confidence 0.30 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.84 Pain Relevance 0.72

General Comments

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