INT247259

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.13
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
dorsal horn 2
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 132 99.04 Very High Very High Very High
intrathecal 28 92.64 High High
Inflammation 68 50.00 Quite Low
Pain 64 5.00 Very Low Very Low Very Low
Serotonin 24 5.00 Very Low Very Low Very Low
central sensitization 24 5.00 Very Low Very Low Very Low
IPN 20 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
Thermal hyperalgesia 12 5.00 Very Low Very Low Very Low
Spinal cord 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 4 66.00 Quite High
Death 4 63.68 Quite High
INFLAMMATION 60 50.00 Quite Low
Pain 64 5.00 Very Low Very Low Very Low
Inflammatory Pain 20 5.00 Very Low Very Low Very Low
Hyperalgesia 12 5.00 Very Low Very Low Very Low
Arthritis 12 5.00 Very Low Very Low Very Low
Hypersensitivity 12 5.00 Very Low Very Low Very Low
Repression 8 5.00 Very Low Very Low Very Low
Nociception 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the levels of P-MeCP2 and Zif268 seen 6 h after CFA were no different from that in naïve animals, there was a significant upregulation in the levels of P-MeCP2, Zif268 and Fos 24 h after CFA (increase to 21 ± 3 immunopositive nuclei (P < 0.01), 31 ± 8 immunopositive nuclei (P < 0.05) and 32 ± 1 (P < 0.01) respectively).


Positive_regulation (upregulation) of Gene_expression (levels) of P-MeCP2
1) Confidence 0.68 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.10
Descending serotonergic inputs are essential for the full expression of P-MeCP2, Zif268 and Fos in the dorsal horn
Positive_regulation (essential) of Gene_expression (expression) of P-MeCP2 in dorsal horn associated with dorsal horn
2) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.13 Pain Relevance 0.17
Although the levels of P-MeCP2 and Zif268 seen 6 h after CFA were no different from that in naïve animals, there was a significant upregulation in the levels of P-MeCP2, Zif268 and Fos 24 h after CFA (increase to 21 ± 3 immunopositive nuclei (P < 0.01), 31 ± 8 immunopositive nuclei (P < 0.05) and 32 ± 1 (P < 0.01) respectively).


Positive_regulation (increase) of Gene_expression (levels) of P-MeCP2
3) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.10
Although the levels of P-MeCP2 and Zif268 seen 6 h after CFA were no different from that in naïve animals, there was a significant upregulation in the levels of P-MeCP2, Zif268 and Fos 24 h after CFA (increase to 21 ± 3 immunopositive nuclei (P < 0.01), 31 ± 8 immunopositive nuclei (P < 0.05) and 32 ± 1 (P < 0.01) respectively).


Positive_regulation (was) of Gene_expression (levels) of P-MeCP2
4) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.10

General Comments

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