INT247261

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.71
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
dorsal horn 3
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 24 99.78 Very High Very High Very High
medulla 12 99.60 Very High Very High Very High
Dorsal horn 132 98.74 Very High Very High Very High
Pain 64 96.92 Very High Very High Very High
Inflammation 68 93.28 High High
IPN 20 87.76 High High
Arthritis 4 59.64 Quite High
Dynorphin 4 56.96 Quite High
bradykinin 4 51.20 Quite High
Spinal cord 8 38.48 Quite Low
Disease Link Frequency Relevance Heat
Pain 64 96.92 Very High Very High Very High
Injury 8 95.84 Very High Very High Very High
INFLAMMATION 60 93.28 High High
Targeted Disruption 4 88.84 High High
Inflammatory Pain 20 87.76 High High
Repression 8 82.68 Quite High
Arthritis 12 76.00 Quite High
Hypersensitivity 12 58.16 Quite High
Nociception 8 33.60 Quite Low
Hyperalgesia 12 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While a number of transcription factors including Methyl-CpG-binding protein 2 (MeCP2), Zif268 and Fos have been implicated in the regulation of dorsal horn neurone sensitization following injury, modulation of their activity by descending controls has not been investigated.


Negative_regulation (number) of MeCP2 in dorsal horn associated with injury and dorsal horn
1) Confidence 0.42 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2553762 Disease Relevance 0.43 Pain Relevance 0.45
While a number of transcription factors including Methyl-CpG-binding protein 2 (MeCP2), Zif268 and Fos have been implicated in the regulation of dorsal horn neurone sensitization following injury, modulation of their activity by descending controls has not been investigated.


Negative_regulation (number) of Methyl-CpG-binding protein 2 in dorsal horn associated with injury and dorsal horn
2) Confidence 0.42 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2553762 Disease Relevance 0.43 Pain Relevance 0.45
In the present study, we were able to show that serotonin depletion attenuated both MeCP2 activation and the increased mechanical sensitivity that follows CFA injection, again strengthening the correlation between transcription factors activation and changes in behaviour.
Negative_regulation (attenuated) of MeCP2 associated with serotonin
3) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.85 Pain Relevance 0.80
The only other significant changes across the dorsal horn were seen in lamina 3–4, 6 h after CFA injection (significant decrease in P-MeCP2 compared to naïve from 17 ± 4 to 5.2 ± 0.4 immunopositive nuclei).
Negative_regulation (decrease) of P-MeCP2 in dorsal horn associated with dorsal horn
4) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0 Pain Relevance 0.09

General Comments

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