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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 6 99.78 Very High Very High Very High
Pain 16 96.92 Very High Very High Very High
Inflammation 17 93.28 High High
IPN 5 87.76 High High
Dorsal horn 33 86.80 High High
Arthritis 1 59.64 Quite High
Dynorphin 1 57.84 Quite High
bradykinin 1 52.08 Quite High
central sensitization 6 34.00 Quite Low
long-term potentiation 1 26.56 Quite Low
Disease Link Frequency Relevance Heat
Pain 16 96.92 Very High Very High Very High
INFLAMMATION 15 93.28 High High
Targeted Disruption 1 88.84 High High
Inflammatory Pain 5 87.76 High High
Repression 2 82.68 Quite High
Arthritis 3 76.00 Quite High
Hypersensitivity 3 58.16 Quite High
Nociception 2 34.48 Quite Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we were able to show that serotonin depletion attenuated both MeCP2 activation and the increased mechanical sensitivity that follows CFA injection, again strengthening the correlation between transcription factors activation and changes in behaviour.
Negative_regulation (attenuated) of Positive_regulation (activation) of MeCP2 associated with serotonin
1) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.85 Pain Relevance 0.80

General Comments

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