INT247263

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.31
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
neurite 2
lamina 1
dorsal horn 1
Mecp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 51 95.72 Very High Very High Very High
Dorsal horn 99 94.88 High High
intrathecal 21 94.84 High High
Thermal hyperalgesia 9 89.60 High High
withdrawal 3 84.60 Quite High
Pain 48 82.32 Quite High
GABAergic 2 73.52 Quite High
gABA 14 69.56 Quite High
bDMF 32 65.72 Quite High
noradrenaline 5 64.68 Quite High
Disease Link Frequency Relevance Heat
Intellectual Impairment 2 99.32 Very High Very High Very High
Neurodegenerative Disease 8 99.10 Very High Very High Very High
INFLAMMATION 45 95.72 Very High Very High Very High
Hyperalgesia 9 89.60 High High
Manic Depressive Disorder 250 83.52 Quite High
Pain 48 82.32 Quite High
Nervous System Injury 3 72.24 Quite High
Death 5 70.64 Quite High
Hypertrophy 3 69.72 Quite High
Toxicity 5 61.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When we plotted the mean number per dorsal horn section, ipsilateral to the CFA injection, of P-MeCP2 positive nuclei against the number of Zif268 or Fos positive nuclei for individual animals for this experiment (N = 10), the correlation was stronger between P-MeCP2 and Zif268 (correlation coefficient: R2 = 0.8) than between P-MeCP2 and Fos (R2 = 0.4), suggesting a parallel regulation for P-MeCP2 and Zif268 (Figure 8).


Regulation (regulation) of P-MeCP2 in dorsal horn associated with dorsal horn
1) Confidence 0.60 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.39 Pain Relevance 0.43
Changes in P-MeCP2, Zif268 and Fos expression were quantified by immunohistochemistry.
Regulation (Changes) of P-MeCP2
2) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.06 Pain Relevance 0.21
Crucially, P-MeCP2, Zif268 and Fos are all up-regulated in lamina I, NK1 positive, projection neurones following peripheral noxious stimulation: after peripheral inflammation 47% and 27% of projection neurones expressed Zif268 [30] and P-MeCP2 [7] respectively.
Regulation (regulated) of P-MeCP2 in lamina associated with inflammation
3) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.30 Pain Relevance 0.41
Among their functions, miRNAs have been shown to regulate neurite outgrowth, neurogenesis and synaptic plasticity, mainly through the regulation of mediators such as CREB, methyl CpG binding protein 2 (MECP2), the fragile X mental retardation 1 protein (FMRP) and elements of the Wnt pathway [156].
Regulation (regulation) of MECP2 in neurite associated with intellectual impairment and neurodegenerative disease
4) Confidence 0.33 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.28 Pain Relevance 0.14
Among their functions, miRNAs have been shown to regulate neurite outgrowth, neurogenesis and synaptic plasticity, mainly through the regulation of mediators such as CREB, methyl CpG binding protein 2 (MECP2), the fragile X mental retardation 1 protein (FMRP) and elements of the Wnt pathway [156].
Regulation (regulation) of CpG binding protein 2 in neurite associated with intellectual impairment and neurodegenerative disease
5) Confidence 0.29 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.28 Pain Relevance 0.14

General Comments

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