INT247265

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (Mecp2, Fos) response to stress (Mecp2, Fos) nucleus (Mecp2, Fos)
transcription factor binding (Mecp2, Fos) aging (Fos) enzyme binding (Mecp2)
Anatomy Link Frequency
brain 1
Mecp2 (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 5 93.44 High High
Hippocampus 2 88.24 High High
long-term potentiation 1 86.40 High High
Serotonin 6 79.44 Quite High
Inflammation 17 77.40 Quite High
bradykinin 1 73.16 Quite High
Dynorphin 1 70.24 Quite High
Dorsal horn 33 67.20 Quite High
Pain 16 65.60 Quite High
intrathecal 7 41.04 Quite Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 5 93.44 High High
Nociception 2 82.00 Quite High
INFLAMMATION 15 77.40 Quite High
Pain 16 65.60 Quite High
Targeted Disruption 1 36.36 Quite Low
Repression 2 30.20 Quite Low
Arthritis 3 23.52 Low Low
Hypersensitivity 3 5.68 Low Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possibility that Fos is a target gene for MeCP2 has been excluded by previous in vitro studies [6] and recent studies of gene expression changes in brain tissue of MeCP2 deficient mice failed to report any changes in Fos and Zif268 mRNA [26].
MeCP2 Regulation (target) of Fos in brain
1) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.38 Pain Relevance 0.52

General Comments

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