INT247294

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 1.80
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HRAS) signal transduction (HRAS) Golgi apparatus (HRAS)
plasma membrane (HRAS) nucleus (HRAS) GTPase activity (HRAS)
Anatomy Link Frequency
synovium 4
HRAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 98 99.98 Very High Very High Very High
cytokine 7 85.68 High High
metalloproteinase 7 85.08 High High
Inflammation 21 84.36 Quite High
Pain 56 80.68 Quite High
Analgesic 7 32.72 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 126 99.98 Very High Very High Very High
Necrosis 7 87.16 High High
Cancer 7 86.80 High High
INFLAMMATION 21 84.36 Quite High
Pain 56 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In accordance with Recklies et al. our results demonstrate that all 3 isoforms of HAS, the enzyme responsible for the synthesis of HA, are expressed by synovium [28].
Regulation (responsible) of Gene_expression (synthesis) of HA in synovium
1) Confidence 0.04 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.50 Pain Relevance 0.20
In the second series of experiments (N = 6 patients) we investigated the effect of different GlcN concentrations on HA production.
Spec (investigated) Regulation (effect) of Gene_expression (production) of HA
2) Confidence 0.04 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0 Pain Relevance 0
In the first series of experiments (N = 6 patients) the effect of different GlcN derivatives on HA production was studied.
Regulation (effect) of Gene_expression (production) of HA
3) Confidence 0.04 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.05 Pain Relevance 0.03
Being a rate-limiting precursor in HA synthesis, GlcN was suggested earlier to exert its effects in OA influencing synovial HA synthesis [18,19].
Regulation (influencing) of Gene_expression (synthesis) of HA associated with osteoarthritis
4) Confidence 0.04 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.31 Pain Relevance 0.17
Being a rate-limiting precursor in HA synthesis, GlcN was suggested earlier to exert its effects in OA influencing synovial HA synthesis [18,19].
Regulation (limiting) of Gene_expression (synthesis) of HA associated with osteoarthritis
5) Confidence 0.03 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.31 Pain Relevance 0.17
Therefore, future studies should look into the effect of lower GlcN concentrations on synovial HA production.
Regulation (effect) of Gene_expression (production) of HA
6) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.09 Pain Relevance 0.05
The aim our study was to evaluate whether GlcN derivatives have an effect on HA production in a human synovium explant model.
Spec (whether) Regulation (effect) of Gene_expression (production) of HA in synovium
7) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.55 Pain Relevance 0.41

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