INT247307

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.11
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Msx1) nucleus (Msx1) DNA binding (Msx1)
Anatomy Link Frequency
midbrain 1
Msx1 (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 20 99.34 Very High Very High Very High
agonist 2 97.78 Very High Very High Very High
melanocortin 1 receptor 4 88.08 High High
Dopamine 83 84.20 Quite High
Action potential 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Freckles 26 57.04 Quite High
Neurodegenerative Disease 7 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low
Mucocutaneous Lymph Node Syndrome 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exclusion of SDF-1 or EFNB1 also had the largest effect on generation of midbrain NPC as indicated by 86% and 85% decrease in Msx1+ colonies, respectively, as compared to treatment with all four factors (Fig. 3I).
Negative_regulation (decrease) of Msx1 in midbrain associated with midbrain
1) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.15
High activity of MC1R (either due to the presence of MSH agonist or high intrinsic MC1R activity) leads to synthesis of black/brown eumelanin, whereas low activity (due to an absence of MSH or presence of ASIP inhibitor) leads either to synthesis of reddish phaeomelanin, or an absence of melanin synthesis.
Negative_regulation (inhibitor) of MSH associated with agonist
2) Confidence 0.03 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2553801 Disease Relevance 0.06 Pain Relevance 0.14
High activity of MC1R (either due to the presence of MSH agonist or high intrinsic MC1R activity) leads to synthesis of black/brown eumelanin, whereas low activity (due to an absence of MSH or presence of ASIP inhibitor) leads either to synthesis of reddish phaeomelanin, or an absence of melanin synthesis.
Negative_regulation (absence) of MSH associated with agonist
3) Confidence 0.03 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2553801 Disease Relevance 0.05 Pain Relevance 0.14

General Comments

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