INT24740

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Context Info
Confidence 0.48
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 14.71
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd79a)
Anatomy Link Frequency
T-cell 3
intestine 2
B cells 2
lung 2
plasma cells 1
Cd79a (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 65 99.60 Very High Very High Very High
Inflammation 94 99.54 Very High Very High Very High
cytokine 322 97.28 Very High Very High Very High
rheumatoid arthritis 6 96.36 Very High Very High Very High
Osteoarthritis 1 95.92 Very High Very High Very High
spinal inflammation 1 95.16 Very High Very High Very High
imagery 3 94.48 High High
tolerance 8 94.00 High High
Pain 8 91.84 High High
Potency 7 76.16 Quite High
Disease Link Frequency Relevance Heat
Immunization 487 99.98 Very High Very High Very High
Sprains And Strains 221 99.98 Very High Very High Very High
Body Weight 59 99.88 Very High Very High Very High
Celiac Disease 42 99.80 Very High Very High Very High
INFLAMMATION 89 99.54 Very High Very High Very High
Infection 587 99.20 Very High Very High Very High
Brain Tumor 3 98.28 Very High Very High Very High
Chlamydia Infection 243 97.88 Very High Very High Very High
Asthma 3 96.88 Very High Very High Very High
Rheumatoid Arthritis 7 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate the ability of orally administered HET to act as a mucosal adjuvant for the induction of specific IgA antibody responses in distant mucosal tissues.


Positive_regulation (induction) of IgA
1) Confidence 0.48 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.08 Pain Relevance 0
Elevated levels of IgG-, IgA-, and IgM-RF could be demonstrated in respectively 94%, 91% and 98% of serum samples from RA patients with a positive latex test and in 72%, 69% and 8% of serum samples from RA patients with a negative latex test.
Positive_regulation (levels) of IgA associated with rheumatoid arthritis
2) Confidence 0.35 Published 1989 Journal Br. J. Rheumatol. Section Abstract Doc Link 2472849 Disease Relevance 0.91 Pain Relevance 0.33
To clarify the mechanisms of enhancement of mucosal IgA antibody response by HET, we studied the effect of HET on modulation of Th1-Th2 balance.
Positive_regulation (enhancement) of IgA
3) Confidence 0.35 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.08 Pain Relevance 0
These polysaccharides may play a role in the enhancement of IgA response via a polyclonal B cell activation as active constituents in HET.
Positive_regulation (enhancement) of IgA in B cell
4) Confidence 0.35 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.06 Pain Relevance 0
, and the enhanced pIgR might partly contribute to the enhanced IgA immune response.
Positive_regulation (enhanced) of IgA
5) Confidence 0.35 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.13 Pain Relevance 0.10
However, oral administration of OVA alone is difficult to induce IgA immune response in gastric mucosa, because a small amount of the aqueous OVA antigen can be easily degraded in the digestive tract (17).
Positive_regulation (induce) of IgA in digestive tract
6) Confidence 0.35 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.05 Pain Relevance 0
Therefore, to induce the OVA-specific IgA antibody in mucosal site, OVA was entrapped into microparticles and then administered orally.
Positive_regulation (induce) of IgA
7) Confidence 0.32 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.09 Pain Relevance 0.03
By oral immunization of OVA-microparticle, OVA-specific IgA antibody was successfully induced in intestine (Fig. 3A).
Positive_regulation (induced) of IgA in intestine associated with immunization
8) Confidence 0.32 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.37 Pain Relevance 0
By oral immunization of OVA-microparticle, OVA-specific IgA antibody was successfully induced in intestine and OVA-specific IgA titers in intestinal washes were significantly enhanced by oral administration of HET.
Positive_regulation (induced) of IgA in intestine associated with immunization
9) Confidence 0.32 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.22 Pain Relevance 0.09
As such locally produced Abs, particularly J-chain associated IgA and IgM, can be expected to be delivered more effectively into the airway lumen than into the intravascular compartment, serum Ab titers do not provide a reliable measure of the locally produced fraction of Abs.
Positive_regulation (associated) of IgA in lumen
10) Confidence 0.32 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0 Pain Relevance 0
One possible explanation for this difference in protection between actively and passively immunized mice was that active immunization induced substantial levels of M2e(pep-nat)-specific IgA.
Positive_regulation (induced) of IgA associated with immunization
11) Confidence 0.28 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.10 Pain Relevance 0
Modification of the virus induced a slight increase of IgA in the presence of pre-existing immunity with respect to that seen in naïve animals given unmodified virus (Vaccine, Figure 6D) and those with pre-existing immunity (Vaccine+PEI).
Positive_regulation (increase) of IgA
12) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.28 Pain Relevance 0
Mucosal, as opposed to systemic vaccination is often more efficacious against mucosal pathogens due to their ability to induce secretory IgA [1], [2].
Positive_regulation (induce) of IgA
13) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.51 Pain Relevance 0.07
Colorimetric values were converted to nanograms/milliliter, according to the standard curves generated for IgG, IgM and IgA.
Positive_regulation (generated) of IgA
14) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0.24 Pain Relevance 0.14
Although we did not observe any significant IgA levels in the mucosa (data not shown), It is likely that one immunization is not sufficient to induce high IgA titers.
Positive_regulation (induce) of IgA associated with immunization
15) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.49 Pain Relevance 0
H5 virus-specific IgG and IgA antibodies were induced faster and accumulated to higher levels at mucosal sites of previously VLP immunized mice (H5VLP+H5i) as compared to the PBS control mice (PBS+H5i).
Positive_regulation (induced) of IgA
16) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.29 Pain Relevance 0.04
H5 virus-specific IgG and IgA antibodies were induced faster and accumulated to higher levels at mucosal sites of previously VLP immunized mice (H5VLP+H5i) as compared to the PBS control mice (PBS+H5i).
Positive_regulation (accumulated) of IgA
17) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.29 Pain Relevance 0.04
H5 virus-specific IgA antibodies were also induced in lung extracts (Fig. 8B).
Positive_regulation (induced) of IgA in lung
18) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.23 Pain Relevance 0
However, while only 20% of CD patients had IgA reactive with neurons, 60% had IgG reactive with neurons.
Positive_regulation (had) of IgA in neurons associated with celiac disease
19) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837746 Disease Relevance 0.66 Pain Relevance 0.04
In contrast, mice i.n infected with MoPn induced high levels of IgA directed to EBs in both serum and vaginal wash.
Positive_regulation (induced) of IgA
20) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.38 Pain Relevance 0

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