INT24741

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Context Info
Confidence 0.17
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 18.23
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 2
articular 1
blood 1
erythrocyte 1
Rf (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 31 99.56 Very High Very High Very High
rheumatoid arthritis 264 98.92 Very High Very High Very High
Inflammation 21 97.56 Very High Very High Very High
headache 6 92.48 High High
Pain 28 89.24 High High
Osteoarthritis 45 85.40 High High
spinal inflammation 14 84.64 Quite High
Snapping jaw 3 83.16 Quite High
cINOD 13 75.28 Quite High
Myofascial pain syndrome 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Mental Disorders 70 100.00 Very High Very High Very High
Anaemia 3 100.00 Very High Very High Very High
Nicotine Addiction 34 99.88 Very High Very High Very High
Arthritis 21 99.56 Very High Very High Very High
Arthralgia 11 99.56 Very High Very High Very High
Polymyalgia Rheumatica 36 99.36 Very High Very High Very High
Depression 16 99.28 Very High Very High Very High
Recurrence 10 99.28 Very High Very High Very High
Rheumatoid Arthritis 300 99.00 Very High Very High Very High
Chronic Hepatitis 1 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the latter patient group, increased levels of one or more RF isotypes could be detected in 82% of the patients.
Positive_regulation (increased) of RF
1) Confidence 0.17 Published 1989 Journal Br. J. Rheumatol. Section Abstract Doc Link 2472849 Disease Relevance 0.86 Pain Relevance 0.30
It was also the strongest predictor for four of the six indicators of poor mental health – RF lack of energy (3.4), RF worried/tense/anxious (2.6), RF lack of rest/sleep (2.8), and major depressive episode (3.3) and is significantly elevated for RF poor mental health (2.2) and for RF sad/blue/depressed (2.5).
Positive_regulation (elevated) of RF associated with mental disorders, depression and fatigue
2) Confidence 0.12 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1431510 Disease Relevance 0.70 Pain Relevance 0.09
It was also the strongest predictor for four of the six indicators of poor mental health – RF lack of energy (3.4), RF worried/tense/anxious (2.6), RF lack of rest/sleep (2.8), and major depressive episode (3.3) and is significantly elevated for RF poor mental health (2.2) and for RF sad/blue/depressed (2.5).
Positive_regulation (elevated) of RF associated with mental disorders, depression and fatigue
3) Confidence 0.12 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1431510 Disease Relevance 0.70 Pain Relevance 0.09
Therefore, it is speculated that this case in unlikely to develope RA and assessment of arthritis corresponding to the elevation of RF is important to differentiate PMR and elderly-onset RA.
Positive_regulation (elevation) of RF associated with polymyalgia rheumatica, rheumatoid arthritis and arthritis
4) Confidence 0.08 Published 1997 Journal Ryumachi Section Abstract Doc Link 9396372 Disease Relevance 1.54 Pain Relevance 0.09
As for polymyalgia rheumatica (PMR) followed by RA, the appearance or exacerbation of arthritis corresponding to the elevation of RF occurred in all previously reported 17 cases.
Positive_regulation (elevation) of RF associated with polymyalgia rheumatica, rheumatoid arthritis and arthritis
5) Confidence 0.08 Published 1997 Journal Ryumachi Section Abstract Doc Link 9396372 Disease Relevance 1.62 Pain Relevance 0.21
Serological testing included HLA subtype, positive (ANA) antinuclear antibody, erythrocyte sedimentation rate (ESR), anemia profile, hormonal levels of prolactin and estradiol, and rheumatoid factor (RF).
Positive_regulation (included) of RF in erythrocyte associated with anaemia
6) Confidence 0.06 Published 1998 Journal Cranio Section Abstract Doc Link 9481984 Disease Relevance 1.29 Pain Relevance 0.43
There was a statistically significant increase in RF positivity and HAQ scores in the group with higher DAS 28 score.
Positive_regulation (increase) of RF
7) Confidence 0.06 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18357499 Disease Relevance 1.47 Pain Relevance 0.75
A small but significant reduction in circulating RF-IgM, anti-CCP IgG, and total IgM, but not total IgG, was observed (Figure 6a).
Positive_regulation (circulating) of RF
8) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.06 Pain Relevance 0
Despite the considerable clinical improvement induced by rituximab treatment, as well as the almost complete depletion of circulating B cells [3,4], only modest, albeit significant, decreases in circulating RF and anti-CCP were observed [5] and levels of these autoantibodies were still highly elevated compared with normal controls.
Positive_regulation (circulating) of RF in B cells
9) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.14 Pain Relevance 0.07
This case of PMR is the 5th case with excessive increase of RF in Japan.
Positive_regulation (increase) of RF associated with polymyalgia rheumatica
10) Confidence 0.05 Published 1997 Journal Ryumachi Section Abstract Doc Link 9396372 Disease Relevance 1.32 Pain Relevance 0.09
Though she had excessive increase of RF (RAHA x 10240) during therapy, no recurrence of articular symptoms were recognized.
Positive_regulation (increase) of RF in articular associated with recurrence
11) Confidence 0.05 Published 1997 Journal Ryumachi Section Abstract Doc Link 9396372 Disease Relevance 1.31 Pain Relevance 0.19
Recurrence of arthralgia corresponding to the elevation of RF was not recognized in this case.
Positive_regulation (elevation) of RF associated with arthralgia and recurrence
12) Confidence 0.05 Published 1997 Journal Ryumachi Section Abstract Doc Link 9396372 Disease Relevance 1.62 Pain Relevance 0.21
The combination of increased RF-PFC and decreased SBF suggests that there is defective B cell autoregulation in RA, which may be involved in the pathogenesis and chronicity of this disease.
Positive_regulation (increased) of RF in B cell associated with rheumatoid arthritis and disease
13) Confidence 0.02 Published 1986 Journal J. Immunol. Section Abstract Doc Link 3485142 Disease Relevance 1.02 Pain Relevance 0.56
To assess IC-mediated feedback suppression in RA, we evaluated the ability of a suppressive B cell factor (SBF) generated by culturing heat-aggregated IgG (HAIgG) with peripheral blood mononuclear leukocytes (PBL) from patients with RA and normal controls to suppress the pokeweed mitogen (PWM)-induced RF plaque-forming cell (PFC) response of normal PBL.
Positive_regulation (-induced) of RF in blood associated with rheumatoid arthritis
14) Confidence 0.02 Published 1986 Journal J. Immunol. Section Abstract Doc Link 3485142 Disease Relevance 1.04 Pain Relevance 0.61
Even in healthy people, RF levels increase with age, and positive reactions can be seen in 5% of young people and up to 25% of the elderly.
Positive_regulation (increase) of RF
15) Confidence 0.02 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815829 Disease Relevance 1.68 Pain Relevance 0.44
Among them, smoking is a risk factors for RA, and this is evidenced by the fact that smokers have increased levels of RF (67–69) and are prone to develop RA (70–72).
Positive_regulation (increased) of RF associated with nicotine addiction and rheumatoid arthritis
16) Confidence 0.01 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717818 Disease Relevance 1.86 Pain Relevance 0.63

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