INT247414

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.23
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cell 6
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 33 77.56 Quite High
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 25 99.98 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 46 92.88 High High
Immunodeficiency 1 92.28 High High
INFLAMMATION 33 77.56 Quite High
Hypertriglyceridemia 4 65.76 Quite High
Nicotine Addiction 8 62.08 Quite High
Cardiovascular Disease 33 59.44 Quite High
Coronary Artery Disease 17 57.84 Quite High
Dyslipidemia /

Combined Dyslipidemia

16 50.00 Quite Low
Diabetes Mellitus 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of a CD4+ T lymphocyte requires the presentation of the adequate MHC class II-peptide complex (specifically recognized by the TCR of the T cell) by a mature recipient antigen presenting cells (APC) expressing costimulatory molecules [25].
Positive_regulation (requires) of Positive_regulation (activation) of CD4 in T lymphocyte
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0
Accordingly, we observed a drastic increase in the percentage of activated CD4+ T cell in intragraft TLT, in both murine experimental model and human samples.
Positive_regulation (increase) of Positive_regulation (activated) of CD4 in T cell
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0 Pain Relevance 0
In particular, TLT CD4+ T cell activation i) is quantitatively increased, ii) is characterized by the activation of a broader range of T cell clones, iii) is stochastic, i.e. characterized by the absence of shared pattern of TCR perturbation in genetically identical couples of donors and recipients.
Positive_regulation (increased) of Positive_regulation (activation) of CD4 in T cell
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0.08 Pain Relevance 0.04
Overall, the adjusted risk of having elevated total cholesterol increased by 31% per twofold increase in CD4 cell count [OR, 1.31; IC95%: 1.16-1.47 per log2CD4, P < 0.001] (Fig. 1).
Positive_regulation (increased) of Positive_regulation (increase) of CD4 associated with disorder of lipid metabolism
4) Confidence 0.26 Published 2008 Journal The Open AIDS Journal Section Body Doc Link PMC2556198 Disease Relevance 1.16 Pain Relevance 0

General Comments

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