INT247431

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RB1) DNA binding (RB1) nucleus (RB1)
molecular_function (RB1) cell division (RB1) cellular_component (RB1)
RB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 1 33.52 Quite Low
positron emission tomography 4 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 2 99.92 Very High Very High Very High
Congenital Anomalies 6 99.18 Very High Very High Very High
Testicular Cancer 147 97.62 Very High Very High Very High
Cancer 66 93.88 High High
Skin Cancer 84 89.24 High High
Carcinoma In Situ 8 84.32 Quite High
Seminoma 32 83.36 Quite High
Disease 32 77.80 Quite High
Death 1 72.68 Quite High
Pancreatic Cancer 7 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of those proteins is p16INK4A, which inhibits the CDK4/6 mediated phosphorilation and inactivation of Rb (retinoblastoma) protein.
Positive_regulation (mediated) of Negative_regulation (inactivation) of Rb associated with retinoblastoma
1) Confidence 0.45 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2556318 Disease Relevance 1.15 Pain Relevance 0
In particular, TGCT has been shown to be associated with a characteristic series of abnormalities in the retinoblastoma pathway including upregulation of cyclin D2 and p27 and downregulation of RB1 and the cyclin-dependent kinase inhibitors of p16, p18, p19 and p21 [13].
Positive_regulation (upregulation) of Negative_regulation (downregulation) of RB1 associated with congenital anomalies, testicular cancer and retinoblastoma
2) Confidence 0.23 Published 2008 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2735737 Disease Relevance 1.44 Pain Relevance 0

General Comments

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