INT247438

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (APOB, SACM1L) phosphatase activity (SACM1L) transport (APOB)
small molecule metabolic process (APOB) Golgi apparatus (SACM1L) enzyme binding (APOB)
APOB (Homo sapiens)
SACM1L (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 112 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 88 100.00 Very High Very High Very High
Hypertension 54 100.00 Very High Very High Very High
Reprotox - General 1 2 93.20 High High
Schizophrenia 2 20.00 Low Low
Diabetes Mellitus 28 5.00 Very Low Very Low Very Low
Obesity 20 5.00 Very Low Very Low Very Low
Familial Combined Hyperlipidemia 12 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 12 5.00 Very Low Very Low Very Low
Nicotine Addiction 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study consisting of a cohort of affected sibling pairs selected from Asian Indian families with a strong history of premature CAD, the APOC3, Sac-1 and the ApoA1, -75G>A SNPs along with hypertension were the significant contributory factors to the CAD trait, probably mediated through their association with lipid and lipoprotein traits, particularly TC, TG and Apo B.
Apo B Binding (association) of Sac-1 associated with coronary artery disease, hypertension and disorder of lipid metabolism
1) Confidence 0.28 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 1.02 Pain Relevance 0
Here, the Sac1 and the -75G>A SNPs showed significantly high LOD scores, implying linkage of these two loci to CAD as well as tentative linkage of the Sac1 SNP to TC, HDL-cholesterol and ApoB by QTL analysis.
ApoB Binding (linkage) of Sac1 associated with coronary artery disease and disorder of lipid metabolism
2) Confidence 0.28 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.98 Pain Relevance 0

General Comments

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