INT247439

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.01
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOA1, HSD11B1) endoplasmic reticulum (HSD11B1) enzyme binding (APOA1)
transmembrane transport (APOA1) lipid metabolic process (APOA1) extracellular space (APOA1)
Anatomy Link Frequency
plasma 1
liver 1
intestine 1
APOA1 (Homo sapiens)
HSD11B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 21 62.16 Quite High
Bile 48 8.40 Low Low
cva 21 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
nud 6 5.00 Very Low Very Low Very Low
aspirin 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
pruritus 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 519 100.00 Very High Very High Very High
Cardiovascular Disease 77 99.92 Very High Very High Very High
Coronary Artery Disease 304 89.28 High High
Atherosclerotic Plaque 6 83.08 Quite High
Familial Combined Hyperlipidemia 6 75.56 Quite High
Obesity 16 68.76 Quite High
Hyperlipidemia 30 66.20 Quite High
Appetite Loss 9 62.84 Quite High
INFLAMMATION 24 62.16 Quite High
Dyslipidemia /

Combined Dyslipidemia

47 54.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The two promoter SNPs, -75G>A and +83C>T in the APOA1 gene, have shown strong association with HDL-C and ApoA1 levels [20].
APOA1 Binding (association) of HDL associated with disorder of lipid metabolism
1) Confidence 0.32 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.58 Pain Relevance 0
Levels of apoA-I are strongly associated with those of HDL cholesterol.
apoA-I Binding (associated) of HDL associated with disorder of lipid metabolism
2) Confidence 0.18 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.81 Pain Relevance 0.03
HDL-C is produced in the intestine, liver and plasma as a complex of Apo A lipoproteins, phospholipids and cholesterol.
Apo A Binding (complex) of HDL in plasma associated with disorder of lipid metabolism
3) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.19 Pain Relevance 0
HDL-C is produced in the intestine, liver and plasma as a complex of Apo A lipoproteins, phospholipids and cholesterol.
Apo A Binding (complex) of HDL in liver associated with disorder of lipid metabolism
4) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.19 Pain Relevance 0
HDL-C is produced in the intestine, liver and plasma as a complex of Apo A lipoproteins, phospholipids and cholesterol.
Apo A Binding (complex) of HDL in intestine associated with disorder of lipid metabolism
5) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.19 Pain Relevance 0

General Comments

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