INT247442

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1)
mRNA processing (SNRNP70) RNA binding (SNRNP70) endoplasmic reticulum (HSD11B1)
HSD11B1 (Homo sapiens)
SNRNP70 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 52 100.00 Very High Very High Very High
Coronary Artery Disease 56 99.56 Very High Very High Very High
Reprotox - General 1 1 92.48 High High
Hypertension 27 82.48 Quite High
Schizophrenia 1 19.28 Low Low
Diabetes Mellitus 18 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Obesity 10 5.00 Very Low Very Low Very Low
Familial Combined Hyperlipidemia 6 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two recent GWA studies with up to 18,000 participants [5],[6] report p-values of association for SNP rs174548 with serum low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and total cholesterol levels that range between 1.89×10?
HDL Binding (association) of SNP associated with disorder of lipid metabolism
1) Confidence 0.04 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581785 Disease Relevance 0.33 Pain Relevance 0
Here, the Sac1 and the -75G>A SNPs showed significantly high LOD scores, implying linkage of these two loci to CAD as well as tentative linkage of the Sac1 SNP to TC, HDL-cholesterol and ApoB by QTL analysis.
HDL-cholesterol Binding (linkage) of SNP associated with coronary artery disease and disorder of lipid metabolism
2) Confidence 0.00 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.98 Pain Relevance 0

General Comments

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