INT247452

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 5.71
Pain Relevance 0.22

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lipid binding (APOA5) transport (APOA5) extracellular space (APOA5)
small molecule metabolic process (APOA5) extracellular region (APOA5) enzyme binding (APOA5)
Anatomy Link Frequency
Body 2
smooth muscle 1
cortex 1
APOA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 82.56 Quite High
Dismenorea 12 79.20 Quite High
Mechanotransduction 24 52.32 Quite High
imagery 12 5.00 Very Low Very Low Very Low
Angina 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 132 100.00 Very High Very High Very High
Obesity 30 98.72 Very High Very High Very High
Coronary Artery Disease 168 97.84 Very High Very High Very High
Adhesions 282 97.24 Very High Very High Very High
Familial Combined Hyperlipidemia 18 96.64 Very High Very High Very High
Hypertension 93 93.24 High High
Inflammatory Bowel Disease 18 92.48 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

12 91.44 High High
Polyhydramnios 18 89.88 High High
Pre-term Labor 36 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ApoA: Apolipoprotein A; APOA1: Apolipoprotein A1 gene; APOA5: Apolipoprotein A5 gene; ApoB: Apolipoprotein B; APOC3: Apolipoprotein C3 gene; ASPs: Affected sibling pairs; BMI: Body mass index; CAD: Coronary Artery Disease; FCHL: Familial Combined Hyperlipidemia; HDL-c: High-Density Lipoprotein cholesterol; HTN: Hypertension; IBD: Identity By Descent; IBS: Identity By State.
Gene_expression (gene) of APOA5 in Body associated with inflammatory bowel disease, familial combined hyperlipidemia, coronary artery disease, hypertension, obesity and disorder of lipid metabolism
1) Confidence 0.54 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 1.97 Pain Relevance 0
ApoA: Apolipoprotein A; APOA1: Apolipoprotein A1 gene; APOA5: Apolipoprotein A5 gene; ApoB: Apolipoprotein B; APOC3: Apolipoprotein C3 gene; ASPs: Affected sibling pairs; BMI: Body mass index; CAD: Coronary Artery Disease; FCHL: Familial Combined Hyperlipidemia; HDL-c: High-Density Lipoprotein cholesterol; HTN: Hypertension; IBD: Identity By Descent; IBS: Identity By State.
Gene_expression (gene) of APOA5 in Body associated with inflammatory bowel disease, familial combined hyperlipidemia, coronary artery disease, hypertension, obesity and disorder of lipid metabolism
2) Confidence 0.54 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 2.02 Pain Relevance 0
Subsequently, two promoter SNPs, -75G>A (rs1799837) and +83C>T (rs5069) in the APOA1 gene and the S19W SNP (rs3135506) in exon 2 of the APOA5 gene were also selected for genotyping in this study.
Gene_expression (selected) of APOA5
3) Confidence 0.48 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2556320 Disease Relevance 0.11 Pain Relevance 0
To test whether SmAV expression is gestation-dependent, myometrial strips from nonpregnant, pregnant, not in labor, and pregnant, in-labor women were quick-frozen.
Spec (whether) Gene_expression (expression) of SmAV
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.08 Pain Relevance 0
We have previously shown in the timed pregnant rat model that ERK is targeted to the cell cortex in late term pregnancy [6] and the upregulation of SmAV expression may be one factor that contributes to the targeting of ERK to focal adhesions in a gestation-dependent manner.
Gene_expression (expression) of SmAV in cortex associated with adhesions
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.48 Pain Relevance 0
Gestational upregulation of SmAV expression implies a possible role of this protein during pregnancy.
Gene_expression (expression) of SmAV
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
Gestation-dependent increase in SmAV expression in both human and rat myometrial tissues
Gene_expression (expression) of SmAV
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.28 Pain Relevance 0
To explore the possible function of the gestation-induced increases in SmAV expression in the human, we probed anti-phosphotyrosine immunoprecipitates of control and stretched human myometrial strips (term pregnant, stretched 2x slack length for 7 min) for SmAV.
Gene_expression (expression) of SmAV
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0 Pain Relevance 0
In the present study we report that expression levels of a newly identified smooth muscle protein, SmAV, increase significantly during pregnancy.
Gene_expression (expression) of SmAV in smooth muscle
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.60 Pain Relevance 0.22

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