INT247549

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 8.77
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 120 98.48 Very High Very High Very High
COX2 42 67.84 Quite High
ketamine 10 44.80 Quite Low
Inflammatory response 6 33.20 Quite Low
ischemia 20 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
withdrawal 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 202 100.00 Very High Very High Very High
Infection 534 99.32 Very High Very High Very High
Respiratory Syncytial Virus 594 98.80 Very High Very High Very High
INFLAMMATION 120 98.48 Very High Very High Very High
Coronary Heart Disease 32 96.72 Very High Very High Very High
Sprains And Strains 12 95.76 Very High Very High Very High
Repression 42 94.08 High High
Disease 22 91.40 High High
Cancer 26 83.00 Quite High
American Trypanosomiasis 6 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1).


Transcription (transcription) of Hypoxia Inducible Factor-1 associated with hypoxia
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908132 Disease Relevance 0.39 Pain Relevance 0
The response to hypoxia in tissues is regulated by the heterodimeric transcription factor Hypoxia Inducible Factor-1 (HIF-1).


Transcription (transcription) of HIF-1 associated with hypoxia
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908132 Disease Relevance 0.39 Pain Relevance 0
C-terminal activation domain from interacting with the transcriptional co-activating protein p300 [16], in turn limiting the transcriptional activity of HIF-1 in a normoxic environment [19].
Transcription (activity) of HIF-1
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.33 Pain Relevance 0
Here, we measured transcript levels of control transfected or HIF-1?
Transcription (transcript) of HIF-1
4) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.19 Pain Relevance 0
B is a critical transcriptional activator of HIF-1?
Transcription (transcriptional) of HIF-1
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.03 Pain Relevance 0.17
Here, we measured transcript levels of control transfected or HIF-1?
Transcription (levels) of HIF-1
6) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.18 Pain Relevance 0
in transcriptional induction of HIF-1?
Transcription (transcriptional) of HIF-1
7) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.01 Pain Relevance 0.03
during inflammation [25]–[27], [53], [54], [69] or infections [54], other studies have found a contribution of HIF-1?
Transcription (contribution) of HIF-1 associated with inflammation and infection
8) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.18 Pain Relevance 0.05
Moreover, transcription of known HIF-1?
Transcription (transcription) of HIF-1
9) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 2.00 Pain Relevance 0.11
For microarray analysis, probes were generated from reverse transcription of 20 µg of pooled RNA for each of tTA and tTA/HIF-1?
Transcription (transcription) of HIF-1
10) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.06 Pain Relevance 0

General Comments

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