INT247550

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.21
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nt5e) cytoplasm (Nt5e)
Anatomy Link Frequency
Shields 2
Nt5e (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 93 99.36 Very High Very High Very High
intrathecal 12 99.20 Very High Very High Very High
IPN 12 91.08 High High
withdrawal 12 89.16 High High
Inflammatory response 25 71.76 Quite High
COX2 7 51.20 Quite High
adenocard 90 50.00 Quite Low
Antinociceptive 66 50.00 Quite Low
Pain 6 44.24 Quite Low
agonist 15 32.84 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 117 99.36 Very High Very High Very High
Nervous System Injury 18 98.88 Very High Very High Very High
Pneumonia 48 98.56 Very High Very High Very High
Infection 121 96.72 Very High Very High Very High
Lumbar Puncture Related Headaches 3 94.24 High High
Respiratory Syncytial Virus 99 94.16 High High
Inflammatory Pain 12 91.08 High High
Sprains And Strains 64 87.48 High High
Paralysis 12 86.96 High High
Hypoxia 28 77.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation suggested that exclusion of Ser523 was important for producing a soluble version of NT5E.
Positive_regulation (important) of Gene_expression (producing) of NT5E
1) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
The supernatant containing secreted GST-mNT5E was filtered (0.45 ?
Positive_regulation (filtered) of Gene_expression (filtered) of mNT5E
2) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
We performed spared nerve injury surgeries as described by Shields and colleagues [54]. mNT5E protein was diluted in 0.9% saline for intrathecal injection (5 ?
Positive_regulation (diluted) of Gene_expression (diluted) of mNT5E protein in Shields associated with nervous system injury and intrathecal
3) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.37 Pain Relevance 0.26
These studies revealed significant induction of HIF-1-target genes (VEGF, CD73 or FN1) in control cells, while these responses were abolished in HIF-1?
Positive_regulation (induction) of Gene_expression (genes) of CD73
4) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.06 Pain Relevance 0.03
As a countermeasure, pathogens of the Enterobacteriaceae family such as Klebsiella pneumoniae produce additional siderophores such as yersiniabactin (Ybt) and contain the iroA locus encoding an Ent glycosylase that prevents Lcn2 binding.
Positive_regulation (prevents) of Gene_expression (glycosylase) of Ent
5) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.33 Pain Relevance 0.12
Whether Ent production stimulates Lcn2-dependent inflammation during pneumonia remains to be determined.
Positive_regulation (stimulates) of Spec (Whether) Gene_expression (production) of Ent associated with inflammation and pneumonia
6) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.82 Pain Relevance 0.13
To generate K. pneumoniae producing unmodified Ent that can be bound by Lcn2, the iroA locus was disrupted in the wild type and the ybtS mutant.
Positive_regulation (generate) of Gene_expression (producing) of Ent
7) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.41 Pain Relevance 0.04
Production of either Ent or Gly-Ent was sufficient for maximal growth in Lcn2?
Positive_regulation (sufficient) of Gene_expression (Production) of Ent
8) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.21 Pain Relevance 0.04

General Comments

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