INT247555

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.15
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 10 90.88 High High
ketamine 3 45.72 Quite Low
fibrosis 2 33.92 Quite Low
Inflammation 20 5.00 Very Low Very Low Very Low
COX2 7 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 51 98.62 Very High Very High Very High
Cancer 7 91.52 High High
Cv Unclassified Under Development 26 90.88 High High
Targeted Disruption 24 78.08 Quite High
Von Hippel-lindau Syndrome 2 72.24 Quite High
Respiratory Syncytial Virus 99 64.84 Quite High
Infection 89 64.48 Quite High
Sprains And Strains 6 58.48 Quite High
Volume Depletion And Dehydration 2 56.52 Quite High
Dilated Cardiomyopathy 2 43.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This also allows us to investigate the effects of enhancing HIF-1 activity in the adult animal, avoiding any developmental effects, and modeling the potential use of HIF-1?
Positive_regulation (enhancing) of HIF-1 Binding (activity) of
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.49 Pain Relevance 0.05
For microarray analysis, probes were generated from reverse transcription of 20 µg of pooled RNA for each of tTA and tTA/HIF-1?
Positive_regulation (generated) of HIF-1 Binding (each) of
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.06 Pain Relevance 0
Under hypoxic conditions, hydroxylation is inhibited and the VHL protein does not bind to HIF-1, eventually leading to stabilization of the alpha-subunit, heterodymerization, nuclear translocation and transcription of HIF-dependent genes.
Positive_regulation (leading) of HIF-1 Neg (not) Binding (bind) of associated with hypoxia
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.60 Pain Relevance 0

General Comments

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