INT247568

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.35
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
fibroblast 2
epithelial cells 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 99.74 Very High Very High Very High
COX2 7 98.60 Very High Very High Very High
cytokine 4 97.48 Very High Very High Very High
Inflammation 43 81.64 Quite High
psoriasis 1 49.92 Quite Low
rheumatoid arthritis 2 49.48 Quite Low
methotrexate 2 18.32 Low Low
COX-2 inhibitor 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 91 99.56 Very High Very High Very High
INFLAMMATION 41 99.46 Very High Very High Very High
Cancer 35 99.28 Very High Very High Very High
Respiratory Syncytial Virus 99 99.16 Very High Very High Very High
Age-related Macular Degeneration 38 99.06 Very High Very High Very High
Metastasis 4 97.28 Very High Very High Very High
Adenocarcinoma 4 97.16 Very High Very High Very High
Lung Cancer 4 94.08 High High
Glaucoma 2 93.44 High High
Stress 38 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Photodynamic therapy (PDT) was a common therapy for exudative AMD until it was replaced largely by intravitreal application of vascular endothelial growth factor (VEGF) inhibitors such as ranibizumab [14].
Negative_regulation (application) of Negative_regulation (inhibitors) of vascular endothelial growth factor associated with age-related macular degeneration
1) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697459 Disease Relevance 0.66 Pain Relevance 0
In contrast, COX-2 is an early response gene induced by growth factors, proinflammatory cytokines, tumour promoters and bacterial toxins.9–11 Inhibition of COX-2 by non-steroidal anti-inflammatory drugs (NSAIDs) results in inhibition of angiogenesis and downregulation of angiogenic factors such as VEGF and bFGF-2 (basic fibroblast growth factor).12–14 In human colorectal adenocarcinoma and other malignancies such as breast, cervical, prostate and lung tumours, increased COX-2 expression has been reported.15 16 In mice, inhibition of COX-2 has been shown to protect against intestinal polyposis.17 The precise mechanisms whereby COX-2 contributes to tumourigenesis include effects on the epithelium, but additional effects on non-epithelial populations including the microvascular endothelium have also been suggested.11
Negative_regulation (inhibition) of Negative_regulation (downregulation) of VEGF in fibroblast associated with adenocarcinoma, intestinal polyposis, lung cancer, inflammation, cancer, cinod and cytokine
2) Confidence 0.36 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 1.37 Pain Relevance 0.35
Photodynamic therapy (PDT) was a common therapy for exudative AMD until it was replaced largely by intravitreal application of vascular endothelial growth factor (VEGF) inhibitors such as ranibizumab [14].
Negative_regulation (application) of Negative_regulation (inhibitors) of VEGF associated with age-related macular degeneration
3) Confidence 0.35 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2697459 Disease Relevance 0.66 Pain Relevance 0
Nude mice experiments have shown that inhibition of VEGF pathways markedly decreases angiogenesis and tumour growth [23].
Negative_regulation (decreases) of Negative_regulation (inhibition) of VEGF associated with cancer
4) Confidence 0.18 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.79 Pain Relevance 0
Thus, we measured transcript levels of CD73 [62], VEGF [63], Fibronectin1 (FN1) [64] and COX2 [65] after 24 h of RSV infection of A549 pulmonary epithelial cells using different RSV infection doses (MOI1-5).
Negative_regulation (measured) of Negative_regulation (levels) of VEGF in epithelial cells associated with cox2, infection and respiratory syncytial virus
5) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.85 Pain Relevance 0.08

General Comments

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