INT247576

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 0

cytoplasm (Hif1a, Vbp1) nucleus (Hif1a, Vbp1) unfolded protein binding (Vbp1) cell differentiation (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)

Hif1a (Mus musculus) Vbp1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 20 5.00 COX2 7 5.00 chemokine 2 5.00 ketamine 1 5.00 anesthesia 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Hypoxia 25 99.04 Cancer 3 92.36 Respiratory Syncytial Virus 99 65.68 Infection 89 65.32 INFLAMMATION 20 5.00 Repression 7 5.00 Pneumonia 4 5.00 Viral Infection 3 5.00 Disease 3 5.00 Hepatitis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Under hypoxic conditions, hydroxylation is inhibited and the VHL protein does not bind to HIF-1, eventually leading to stabilization of the alpha-subunit, heterodymerization, nuclear translocation and transcription of HIF-dependent genes.

HIF-1 Neg (not) Binding (bind) of VHL protein associated with hypoxia

1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.60 Pain Relevance 0

General Comments

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