INT247576

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hif1a, Vbp1) nucleus (Hif1a, Vbp1) unfolded protein binding (Vbp1)
cell differentiation (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Hif1a (Mus musculus)
Vbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 5.00 Very Low Very Low Very Low
COX2 7 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 25 99.04 Very High Very High Very High
Cancer 3 92.36 High High
Respiratory Syncytial Virus 99 65.68 Quite High
Infection 89 65.32 Quite High
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Repression 7 5.00 Very Low Very Low Very Low
Pneumonia 4 5.00 Very Low Very Low Very Low
Viral Infection 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Hepatitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under hypoxic conditions, hydroxylation is inhibited and the VHL protein does not bind to HIF-1, eventually leading to stabilization of the alpha-subunit, heterodymerization, nuclear translocation and transcription of HIF-dependent genes.
HIF-1 Neg (not) Binding (bind) of VHL protein associated with hypoxia
1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.60 Pain Relevance 0

General Comments

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