INT247578

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.59
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hif1a, VEGFA) cell differentiation (Hif1a) protein binding transcription factor activity (Hif1a)
DNA binding (Hif1a) signal transducer activity (Hif1a) extracellular space (VEGFA)
Hif1a (Mus musculus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 71.12 Quite High
chemokine 2 16.72 Low Low
COX2 7 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 2 99.44 Very High Very High Very High
Meningitis 1 97.00 Very High Very High Very High
Infection 89 94.28 High High
Viral Infection 3 87.12 High High
Hepatitis 2 79.68 Quite High
Hypoxia 25 79.36 Quite High
INFLAMMATION 20 71.12 Quite High
Respiratory Syncytial Virus 99 65.52 Quite High
Respiratory Disease 1 59.92 Quite High
Necrosis 1 48.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This could have important medical implications in terms of the treatment of sepsis, as it has been shown that serum VEGF levels (known to be regulated via HIF-1) are dramatically increased in patients suffering from septicemia [30] or meningitis [31].
HIF-1 Regulation (regulated) of serum VEGF associated with meningitis and sepsis
1) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.59 Pain Relevance 0.07

General Comments

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